Vitamin d (Cholecalciferol)

Available forms

Manufactured in the skin from cholesterol after exposure to sunligh

Multiple vitamins typically contain 400 IU per dose

Some rodenticides contain cholecalciferol as the active

ingredient

Poisoning Manifestations

Hypercalcemia, hypercalcuria, muscle weakness,

headache, nausea, vomiting, bone pain, proteinuria, renal

compromise, hypertension, and cardiac arrhythmias.

Toxic Dose

Chronic Toxic Dose: 5,000-25,000 IU/day for several

Weeks.

Vitamin d

Treatment

Supportive Care

Hypercalcemia

Loop diuretics, IV fluids and prednisone (20 mg/day)

Preventing absorption

Activated charcoal, lavage, or ipecac syrup

Antidotes

Calcitonin-salmon: 4-8 MRS units/kg every 6 hours

or, pamodrinate 60-90 mg, IV over 2-24 hours for

corrected serum calcium of 12-13 mg/dL