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Drugs affecting bony structure and regulating t...doc
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5.Write prescriptions for next drugs and note their indications and contraindications (precautions):

1. In low and intermittent doses it may actually increase bone formation without first stimulating bone resorption.

2. Its production in the kidney is stimulated by PTH.

3. Natural hormone taken from salmon that is approved for use in the treatment of postmenopausal osteoporosis.

4. It rapidly corrects hypocalcemia and at least partially reverses the secondary hyperparathyroidism caused by renal failure

5. Recombinant human PTH drug for the treatment of osteoporosis.

6. A secosteroid produced in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation.

7. Plant-derived form of vitamin D.

8. Among the inorganic compounds this salt is preferred because of its high percentage of calcium, ready availability (eg, Tums), low cost, and antacid properties.

9. This nonhormonal drug reduces hydroxyapatite formation and dissolution make them clinically useful, particularly, for the treatment of hypercalcemia associated with malignancy, osteoporosis, and syndromes of ectopic calcification.

10. An enolcarboxamide related to piroxicam that is selective COX2 inhibitor.

11. An agent that blocks COX irreversibly.

12. Antiparasitic drug that increases the magnitude of delayed hypersensitivity or T cell-mediated immunity.

13. Endogenous protein that is approved for the treatment of chronic granulomatous disease.

14. Immunosuppressive agent with efficacy in human organ transplantation and in the treatment of selected autoimmune disorders.

15. Glucocorticoid with very low mineralocorticoid activity and very high topical activity; used for dermatologic conditions.

16. The most potent glucocorticoid drug for systemic use.

17. Active metabolite of a synthetic glucocorticoid; has an intermediate duration of action and low topical activity.

18. A drug used by aerosol in the treatment of asthma.

Cholecalciferol [D3] (vitamin D3, Delta-D)

Oral: 400, 1000 IU tablets

Calcitriol

Oral (Rocaltrol): 0.25, 0.5 g capsules, 1 g/mL solution;

Parenteral (Calcijex): 1 g/mL for injection

Ergocalciferol [D2] (vitamin D2, Calciferol, Drisdol)

Oral: 50,000 IU capsules; 8000 IU/mL drops

Parenteral: 500,000 IU/mL for injection

Calcium carbonate [40% calcium] (generic, Tums, Cal-Sup, Os-Cal 500)

Oral: Numerous forms available containing 260–600 mg calcium per unit

Calcitonin-Salmon

Nasal spray (Miacalcin): 200 IU/puff

Parenteral (Calcimar, Miacalcin, Salmonine): 200 IU/mL for injection

Alendronate (Fosamax)

Oral: 5, 10, 35, 40, 70 mg tablets

Parathyreoidine

Parenteral: 25-250 mcg/ml

Nasal spray: 25-250 mcg/ml

Teriparatide

20 mcg subcutaneously once a day into the thigh or abdominal wall by prefilled pen delivery device (pen for 28 days).