Pathogenesis of T. pallidum (cont.) Congenital Syphilis
Congenital syphilis results from transplacental infection
T. pallidum septicemia in the developing fetus and widespread dissemination
Abortion, neonatal mortality, and late mental or physical problems resulting from scars from the active disease and progression of the active disease state
Comparison of
Incidence of 1o
& 2o Syphilis in
Women and
Congenital
Syphilis
Prevention & Treatment of Syphilis
Penicillin remains drug of choice
•WHO monitors treatment recommendations
•7-10 days continuously for early stage
•At least 21 days continuously beyond the early stage
Prevention with barrier methods (e.g., condoms)
Prophylactic treatment of contacts identified through epidemiological tracing
Diagnostic Tests for Syphilis
(Original Wasserman Test)
NOTE: Treponemal antigen tests indicate experience with a treponemal infection, but cross-react with antigens other than T. pallidum ssp. pallidum. Since pinta and yaws are rare in USA, positive treponemal antigen tests are usually indicative of syphilitic infection.
Sensitivity & Specificity of Serologic Tests for Syphillis
Review Handout on Sensitivity & Specificity of Diagnostic Tests
Conditions Associated with False Positive Serological Tests for Syphillis
Effect of Treatment for Syphillis on Rapid Plasma Reagin Test Reactivity
