Practical lesson 2 conversion of α- amino group. Disposal and detoxification of ammonia. Conversion for α- carboxyl group

Choose the correct answer:

1. The cofactor of amino transferases is…

A. TDP;

B. FAD or FMN;

C. NAD⁺ or NADP⁺;

D. PLP;

E. biotin.

2. The most frequently as acceptor for α-amino group … is used.

A. pyruvic acid;

B. oxaloacetate;

C. α-ketoglutarate;

D. aspartate;

E. glutamic amino acid.

3. Glutamate DH is available only in the…

A. liver;

B. kidney;

C. brain;

D. muscle;

E. lung.

4. Molecule trapping ammonia in brain is…

A. pyruvic acid;

B. oxaloacetate;

C. glutamic acid;

D. asparagine;

E. glutamine.

5. Transport form of ammonia from brain to liver is…

A. alanine;

B. glutamic acid;

C. aspartic acid;

D. glutamine;

E. all answers are correct.

6. Transport form of ammonia from muscle to liver is…

A. alanine;

B. glutamic acid;

C. asparagine;

D. glutamine;

E. all answers are correct.

7. Rate-limiting step in urea formation is…

A. carbomoyl phosphate synthetase reaction;

B. ornithine trans carbomoylase reaction;

C. argininosuccinate synthetase reaction;

D. argininosuccinate lyase reaction;

E. arginase reaction.

8. The cofactor of decarboxylases is…

A. NAD⁺;

B. NADP⁺;

C. FAD;

D. FMN;

E. PLP.

9. Allergic reactions can be connected with high levels of …

A. GABA and serotonin;

B. serotonin and histamine;

C. histamine and dopamine;

D. dopamine and GABA;

E. GABA and histamine.

10.In brain tissue as an inhibitory neurotransmitter …. is used.

A. serotonin;

B. histamine;

C. dopamine;

D. GABA;

E. melatonin.

Practical lesson 3 fate of carbon skeletons. Metabolism of methionin, phenylalanine, tyrosine. Transmethylation reactions. Creatine metabolism

1. Which one of the following amino acids is ketogenic?

A. tyrosine;

B. tryptophan;

C. leucine;

D. isoleucine;

E. threonine.

2. All following amino acids are glycogenic and ketogenic, except …

A. tyrosine;

B. isoleucine;

C. tryptophan;

D. phenylalanine;

E. leucine.

3. In Parkinsonism patient has …

A. low level of GABA;

B. high level of serotonin;

C. high level of histamine;

D. low level of dopamine;

E. low level of melanin.

4. Branched chain amino acids are…

A. proline, alanine, serine;

B. alanine, cysteine, serine;

C. serine, threonine, tyrosine;

D. valine, leucine, isoleucine;

E. alanine, serine, valine.

5. Branched chain amino acids are used as…

A. sources of biosynthesis of biogenic amines;

B. sources of fuel for the heart and kidney;

C. sources of fuel for the brain;

D. substrates for gluconeogenesis;

E. substrates for ketogenesis.

6. Patients in Maple syrup disease have defect in….

A. homogentisate oxidase;

B. phenylalanine hydroxylase;

C. tyrosinase;

D. decarboxylase of branched chain keto acids;

E. decarboxylase of GABA.

7. Patients in albinism have defect in…

A. homogentisate oxidase;

B. phenylalanine hydroxylase;

C. tyrosinase;

D. decarboxylase of branched chain keto acids;

E. decarboxylase of GABA.

8. Patients in Alcaptonuria have defect in…

A. homogentisate oxidase;

B. phenylalanine hydroxylase;

C. tyrosinase;

D. decarboxylase of branched chain keto acids;

E. decarboxylase of GABA.

1. Patients in phenylketonuria have defect in…

A. homogentisate oxidase;

B. phenylalanine hydroxylase;

C. tyrosinase;

D. decarboxylase of branched chain keto acids;

E. decarboxylase of GABA.

10. Creatine kinase located in heart has following protomers…

A. MM;

B. HHHM;

C. BB;

D. MB;

E. HHHH.