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Файл:Prescriber's Guide_ Stahl's Ess - Stephen M. Stahl.docx
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- •Table of Contents
- •If It Works 224
- •If It Works 234
- •If It Doesn’t Work 234
- •If It Doesn’t Work 274
- •If It Works 246
- •If It Doesn’t Work 246
- •If It Works 260
- •If It Doesn’t Work 261
- •If It Works 274
- •If It Works 315
- •If It Doesn’t Work 316
- •If It Works 330
- •If It Doesn’t Work 330
- •If It Works 339
- •If It Doesn’t Work 340
- •If It Works 351
- •If It Doesn’t Work 351
- •If It Works 361
- •If It Doesn’t Work 362
- •If It Works 369
- •If It Doesn’t Work 369
- •If It Works 378
- •If It Doesn’t Work 378
- •If It Works 386
- •If It Doesn’t Work 386
- •If It Works 398
- •If It Doesn’t Work 399
- •If It Works 404
- •If It Doesn’t Work 405
- •If It Works 411
- •If It Works 423
- •If It Doesn’t Work 424
- •If It Works 433
- •If It Doesn’t Work 433
- •If It Works 445
- •If It Doesn’t Work 445
- •If It Works 457
- •If It Doesn’t Work 458
- •If It Works 472
- •If It Doesn’t Work 472
- •If It Works 483
- •If It Doesn’t Work 483
- •If It Works 493
- •If It Doesn’t Work 494
- •If It Works 503
- •If It Doesn’t Work 504
- •If It Works 517
- •If It Doesn’t Work 518
- •If It Works 530
- •If It Doesn’t Work 530
- •If It Works 544
- •If It Doesn’t Work 544
- •If It Works 556
- •If It Doesn’t Work 557
- •If It Works 564
- •If It Doesn’t Work 564
- •If It Works 580
- •If It Doesn’t Work 580
- •If It Works 587
- •If It Doesn’t Work 587
- •If It Works 597
- •If It Doesn’t Work 597
- •If It Works 611
- •If It Doesn’t Work 612
- •If It Works 627
- •If It Doesn’t Work 628
- •If It Works 641
- •If It Doesn’t Work 641
- •If It Works 652
- •If It Doesn’t Work 652
- •If It Works 659
- •If It Doesn’t Work 660
- •If It Works 667
- •If It Doesn’t Work 668
- •If It Works 674
- •If It Doesn’t Work 674
- •If It Works 683
- •If It Doesn’t Work 683
- •If It Works 696
- •If It Doesn’t Work 697
- •If It Works 706
- •If It Doesn’t Work 707
- •If It Works 718
- •If It Doesn’t Work 719
- •If It Works 726
- •If It Doesn’t Work 726
- •If It Works 740
- •If It Works 752
- •If It Doesn’t Work 752
- •If It Works 762
- •If It Doesn’t Work 762
- •If It Works 770
- •If It Doesn’t Work 770
- •If It Works 783
- •If It Doesn’t Work 783
- •If It Works 790
- •If It Doesn’t Work 790
- •If It Doesn’t Work 803
- •If It Works 815
- •If It Doesn’t Work 816
- •If It Works 830
- •If It Doesn’t Work 830
- •If It Works 802
- •If It Works 839
- •If It Works 855
- •If It Works 863
- •If It Doesn’t Work 863
- •If It Works 886
- •If It Doesn’t Work 886
- •If It Works 899
- •If It Doesn’t Work 900
- •If It Works 912
- •If It Doesn’t Work 913
- •If It Works 923
- •If It Doesn’t Work 923
- •If It Works 933
- •If It Doesn’t Work 933
- •If It Works 939
- •If It Doesn’t Work 940
- •If It Works 953
- •If It Doesn’t Work 954
- •If It Works 967
- •If It Doesn’t Work 967
- •If It Works 980
- •If It Doesn’t Work 981
- •If It Works 987
- •If It Doesn’t Work 987
- •If It Works 998
- •If It Doesn’t Work 998
- •If It Works 1033
- •If It Doesn’t Work 1033
- •If It Works 1041
- •If It Doesn’t Work 1041
- •If It Works 1048
- •If It Doesn’t Work 1048
- •If It Works 1061
- •If It Doesn’t Work 1061
- •If It Works 1072
- •If It Doesn’t Work 1072
- •If It Works 1085
- •If It Doesn’t Work 1085
- •If It Works 1094
- •If It Doesn’t Work 1095
- •If It Works 1103
- •If It Doesn’t Work 1103
- •If It Works 1110
- •If It Doesn’t Work 1110
- •If It Works 1118
- •If It Doesn’t Work 1119
- •If It Works 1130
- •If It Doesn’t Work 1130
- •If It Works 1144
- •If It Doesn’t Work 1145
- •If It Works 1159
- •If It Doesn’t Work 1160
- •If It Works 1169
- •If It Works 1180
- •If It Doesn’t Work 1180
- •If It Works 1195
- •If It Doesn’t Work 1195
- •If It Works 1209
- •If It Doesn’t Work 1210
- •If It Works 1218
- •If It Doesn’t Work 1219
- •If It Works 1230
- •If It Doesn’t Work 1230
- •If It Works 1244
- •If It Doesn’t Work 1244
- •If It Works 1252
- •If It Doesn’t Work 1253
- •If It Works 1262
- •If It Doesn’t Work 1263
- •If It Works 1272
- •If It Doesn’t Work 1272
- •If It Works 1279
- •If It Works 1288
- •If It Doesn’t Work 1288
- •If It Works 1297
- •If It Doesn’t Work 1297
- •If It Works 1309
- •If It Doesn’t Work 1309
- •If It Works 1317
- •If It Doesn’t Work 1318
- •If It Works 1331
- •If It Doesn’t Work 1331
- •If It Works 1339
- •If It Doesn’t Work 1339
- •If It Works 1349
- •If It Doesn’t Work 1350
- •If It Works 1366
- •If It Doesn’t Work 1366
- •If It Works 1377
- •If It Doesn’t Work 1378
- •If It Works 1396
- •If It Doesn’t Work 1396
- •If It Works 1406
- •If It Doesn’t Work 1406
- •If It Works 1420
- •If It Doesn’t Work 1421
- •If It Works 1428
- •If It Doesn’t Work 1429
- •If It Works 1438
- •If It Doesn’t Work 1438
- •If It Works 1445
- •If It Doesn’t Work 1445
- •If It Works 1456
- •If It Doesn’t Work 1457
- •If It Works 1466
- •If It Works 1476
- •If It Doesn’t Work 1476
- •If It Works 1483
- •If It Works 1494
- •If It Doesn’t Work 1494
- •If It Works 1507
- •If It Doesn’t Work 1507
- •If It Works 1517
- •If It Doesn’t Work 1517
- •If It Works 1525
- •If It Doesn’t Work 1526
- •If It Works 1535
- •If It Doesn’t Work 1535
- •If It Works 1551
- •If It Doesn’t Work 1552
- •If It Works 1565
- •If It Works 1578
- •If It Doesn’t Work 1579
- •If It Works 1586
- •If It Doesn’t Work 1586
- •If It Works 1600
- •If It Doesn’t Work 1600
- •If It Works 1612
- •If It Doesn’t Work 1613
- •If It Works 1623
- •If It Doesn’t Work 1623
- •If It Works 1631
- •If It Doesn’t Work 1632
- •If It Works 1646
- •If It Doesn’t Work 1646
- •If It Works 1655
- •If It Works 1662
- •If It Doesn’t Work 1662
- •If It Works 1670
- •If It Doesn’t Work 1670
- •If It Works 1680
- •If It Doesn’t Work 1681
- •Prescriber’s Guide
- •Stahl’s Essential Psychopharmacology Prescriber’s Guide
- •Contents
- •Introduction
- •Introduction
- •List of icons
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Amisulpride
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Aripiprazole: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Aripiprazole
- •How the Drug Works
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an a typical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Asenapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Asenapine
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Atomoxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting any atypical antipsychotic
- •Monitoring after starting any atypical antipsychotic
- •Dosing Tips
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Bupropion: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work (for bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Chlorpromazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Citalopram: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Clozapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Weight Gain
- •Sedation
- •What to Do About Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Clozapine
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Cyamemazine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Desipramine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Desvenlafaxine: side effects How Drug Causes Side Effects
- •Overdose
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Doxepin: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Duloxetine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Escitalopram: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluoxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Flupenthixol: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluphenazine: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluvoxamine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for neuropathic pain or bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Gabapentin: special populations Renal Impairment
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Haloperidol: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Iloperidone
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance (for bipolar disorder)
- •Weight Gain
- •Sedation
- •What to Do About Side Effects
- •Best Augmenting Agents for Side Effects
- •Lamotrigine: dosing and use Usual Dosage Range
- •Dosage Forms
- •How to Dose
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for bipolar disorder or neuropathic pain)
- •Levetiracetam: special populations Renal Impairment
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Levomilnacipran: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Lisdexamfetamine: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Loxapine: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting any atypical antipsychotic
- •Monitoring after starting any atypical antipsychotic
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Lurasidone
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Mesoridazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •How to Dose
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Milnacipran: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Moclobemide: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Molindone: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Other Warnings/Precautions
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Nefazodone: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Olanzapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Oral Olanzapine
- •Switching from Oral Antipsychotics to Olanzapine lai
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic:
- •Monitoring after starting an atypical antipsychotic:
- •Paliperidone: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Paliperidone er
- •Switching from Oral Antipsychotics to Paliperidone Palmitate
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Paroxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Perphenazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Phenelzine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •Pimozide: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pipothiazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for neuropathic pain)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pregabalin: special populations Renal Impairment
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Protriptyline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Quetiapine: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Quetiapine
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Risperidone: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips – Oral Formulation
- •Dosing Tips – Long-Acting Microsphere Depot Formulation
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Risperidone: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •Switching from Oral Antipsychotics to Risperidone
- •Switching from Oral Antipsychotics to Risperidone lai
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Selegiline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Sertraline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Sertraline: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Sulpiride: side effects How Drug Causes Side Effects
- •Children and Adolescents
- •Pregnancy
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Thioridazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Thiothixene: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work (for neuropathic pain or anxiety disorders)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Pregnancy
- •Breast Feeding
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Trifluoperazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work (for depression)
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Best Augmenting Combos for Partial Response or Treatment Resistance (for bipolar disorder)
- •How to Dose
- •Dosing Tips
- •Other Warnings/Precautions
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Venlafaxine: side effects How Drug Causes Side Effects
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Vilazodone: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Vortioxetine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Ziprasidone: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Ziprasidone: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •Switching from Oral Antipsychotics to Ziprasidone
- •Dosing Tips
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Zotepine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Zuclopenthixol: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Index by Drug Name
- •Index by Use
- •Valproate (divalproex) 711
- •Valproate (divalproex) 711
- •Valproate (divalproex) 711
- •Index by Class
- •Abbreviations
Notable Side Effects
• Sexual dysfunction (men: delayed ejaculation, erectile dysfunction; men and women: decreased sexual desire, anorgasmia)
• Gastrointestinal (decreased appetite, nausea, diarrhea, constipation, dry mouth)
• Mostly central nervous system (insomnia but also sedation, agitation, tremors, headache, dizziness)
• Note: patients with diagnosed or undiagnosed bipolar or psychotic disorders may be more vulnerable to CNS-activating actions of SSRIs
• Autonomic (sweating)
• Bruising and rare bleeding
• Rare hyponatremia (mostly in elderly patients and generally reversible on discontinuation of sertraline)
• Rare hypotension
Life-Threatening or Dangerous Side Effects
• Rare seizures
• Rare induction of mania
• Rare activation of suicidal ideation and behavior (suicidality) (short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo beyond age 24)
Weight Gain
• Reported but not expected
• Some patients may actually experience weight loss
Sedation
• Reported but not expected
• Possibly activating in some patients
What to Do About Side Effects
• Wait
• Wait
• Wait
• If sertraline is activating, take in the morning to help reduce insomnia
• Reduce dose to 25 mg or even 12.5 mg until side effects abate, then increase dose as tolerated, usually to at least 50 mg/day
• In a few weeks, switch or add other drugs
Best Augmenting Agents for Side Effects
• Often best to try another SSRI or another antidepressant monotherapy prior to resorting to augmentation strategies to treat side effects
• Trazodone or a hypnotic for insomnia
• Bupropion, sildenafil, vardenafil, or tadalafil for sexual dysfunction
• Bupropion for emotional flattening, cognitive slowing, or apathy
• Mirtazapine for insomnia, agitation, and gastrointestinal side effects
• Benzodiazepines for jitteriness and anxiety, especially at initiation of treatment and especially for anxious patients
• Many side effects are dose-dependent (i.e., they increase as dose increases, or they reemerge until tolerance redevelops)
• Many side effects are time-dependent (i.e., they start immediately upon dosing and upon each dose increase, but go away with time)
• Activation and agitation may represent the induction of a bipolar state, especially a mixed dysphoric bipolar II condition sometimes associated with suicidal ideation, and require the addition of lithium, a mood stabilizer or an atypical antipsychotic, and/or discontinuation of sertraline
SERTRALINE: DOSING AND USE
Usual Dosage Range
• 50–200 mg/day
Dosage Forms
• Tablets 25 mg scored, 50 mg scored, 100 mg
• Oral solution 20 mg/mL
How to Dose
• Depression and OCD: initial 50 mg/day; usually wait a few weeks to assess drug effects before increasing dose, but can increase once a week; maximum generally 200 mg/day; single dose
• Panic, PTSD, and social anxiety: initial 25 mg/day; increase to 50 mg/day after 1 week thereafter, usually wait a few weeks to assess drug effects before increasing dose; maximum generally 200 mg/day; single dose
• PMDD: initial 50 mg/day; can dose daily through the menstrual cycle or limit to the luteal phase
• Oral solution: mix with 4 oz of water, ginger ale, lemon/lime soda, lemonade, or orange juice only; drink immediately after mixing
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