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  1. Read and translate the following word-combinations:

Pulse, respiratory rate, temperature, weight, length, head circumference and any visible or palpable structural abnormality should be recorded.

Examining the newborn requires patience, gentleness, and procedural flexibility. If the baby is quiet and relaxed at the beginning of the examination, palpation of the abdomen or auscultation of the heart should be performed first before the more disturbing manipulation are done.

General appearance: pallor, jaundice or cyanosis. Features of syndromes like Down’s syndrome, Turner’s syndrome, etc. Is the baby appropriate for the period of gestation: small or large, lanugo or evidence of postmaturity?

Skin: birth marks, miconium staining, cyanosis, subcutaneous bleeding etc.

Head: size, tension of fontanelles, cephalhacmaloma or depressed fractures, head circumference, sternoastoid swelling.

Face: fades, jaws, harelip, ptosis or cataract, subconjunctival hemorrhage.

Arms and hands: proportions of arms or fingers, number of fingers, normal movements, Erb’s palsy, palmar creases, edema.

Chest: distortion, recession, distress, respiratory rate, air entry, additional sounds, etc.

Cardiovascular system: apex, precordial impulse, pulse, heart murmurs.

Legs and feet: proportions of legs and feet, club foot, femoral pulse, test for congenital dislocation of the hip by Ortoloni’s test.

  1. Read the text and give its annotation:

NEONATAL RICKETS

Premature infants can, during the first 3-4 months of life, have hypocalcemia associated with bone hypomineralization or frank rickets. Often there is a history of severe BDP and chronic diuretic therapy. Phosphate deficiency may predominate.

Evaluation

  1. Monitor serum calcium and phosphorus biweekly in infants at risk.

  2. Alkaline phosphatase cannot be used as sole measurement due to pooor correlation with other biochemical and X-ray findings.

  3. Evaluation of bone mineralization is necessary when biochemical abnormalities are noted. Routine X-ray screening at 6-9 weeks can be justified to identify severe osteopenia.

  4. Complete evaluation requires a serum PTH measurement.

  5. Severe demineralization occurs most frequently when a phosphorus deficiency is superimposed on 25-OHD deficiency. Human milk and infant formulas often do not meet the needs of the very small premature infant, leading to classical phosphate-deficiency rickets.

  6. With severe vitamin D deficiency, osteopenia, low normal calcium, low phosphorus, high alkaline phosphatase, and an elevated PTH or generalized aminoaciduria are seen.

Therapy

  1. Infants with rickets or severe osteopenia have been successfully treated with oral vitamin D at dose of 4000 IU\day. Vitamin D deficiency rickets has been treated with oral 1.25- dihydroxy-vitamin D in doses of 0.04 - 0.08 pg/kg/day 9 up to maximum of 1-2 pg/day).

  2. Improved mineralization may be seen on a high calcium-high phosphorus formula with a calcium-phosphorus ratio below 2:1.

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