Immunopathology and immunodeficiency

*01*,*02,*06* Donor skin has been transplanted to a patient with extensive burn. In 4-5 days the skin transplant adapted, but it became swollen and changed color on the eighth day. Ten days later it started to reject. Which cells take part in this process?

A. T-lymphocytes.

B. Erythrocytes.

C. Basophiles.

D. Eosinophils.

E. B-lymphocytes.

*00* Patient after transplantation of kidney graft has rejection. Which major effector cells take part in this immunological reaction?

*Cytotoxic T-cells

B-cells

Plasma cells

Suppressor T -cells

Helper T-cells

*After 1.5 months of liver transplantation the patient state was getting worse due to onset of graft rejection. Which factor of immune system acts the predominant part in this reaction?

T-killers

Interleukin-I

Natural killers

B-cells

T-helpers

*The boy, 11 years old, has ekzematous rash onto the trunk and legs. History revealed otitis, pneumonia, furunculosis. Laboratory assay shows thrombocytopenia, low activity of T-helpers and T-suppressors, decreasing of IgM level at normal data for Iga and IgG. Which type of immunodeficiency is at this case?

Wiskott-Aldrich syndrome

Louis-Barr syndrome

DeGeorgy syndrome

Chediak-Higashi syndrome

Swiss syndrome

The child, 2 years old, suffering from severe form of chicken pox, has face defects, mongoloid slant. History revealed spasms, oral cavity mycosis . There is lymphocytopenia at normal level of B-cells and immunoglobulins into the blood assay. Which immunodeficiency syndrome does child have?

DiGeorgy syndrome

Wiskott-Aldrich syndrome

Louis-Barr syndrome

Kleinefelter’s syndrome

Shereshevsky- Turner’s syndrome

*07* 64. Immunological tests of a patient with clinical symptoms of immunodeficiency have been carried out. Significant decrease of cells, forming rosettes with sheep erythrocytes, has been revealed. What conclusion should be made on the basis of analysis data?

Decrease of complement system level.

Decrease of B-cells level.

Decrease of natural killers (NK-cells) level.

Decrease of T-cells level.

Decrease of thrombocytes (platelets) quantity

*03* 41. A patient with clinical symptoms of immunodeficiency with invariable quantity and functional activity of T-and B-cells is found to have a molecular level defect. This defect is accompanied by the disorder of antigen-presenting function of immunocompetent cells. Name these cells.

NK-cells.

T- and B-lymphocytes.

Macrophages and monocytes.

Fibroblasts, T- and B-lymphocytes.

B-lymphocytes.

*05* A patient with clinical symptoms of primary immunodeficiency is found to have a defect of antigen-presenting function of immunocompetent cells. The structure defect of what cells is possible?

NK-cells

В- cells

Т- cells

Plasma cells

*Macrophages, monocytes

42. Acquired defect of immune system of a patient is diagnosed - a disorder of complement system activation by the classical pathway against the background of the sufficient content of system components. Defect of antibody production is suspected. Decrease in number of what antibodies can be expected first of all?

A. IgM, IgA.

B.IgA, IgG.

C.IgD, IgG.

D.IgE, IgG.

E. IgM, IgG.

53. A 37-year-old woman periodically had infectious diseases of bacterial genesis during a year. Their clinical course was extremely prolonged, remissions were short-term. Hypogamma­ globulinemia was revealed by examination. The functional defect of what cells might be the direct cause of the disease?

A. Neutrophiles.

B. Eosinophils.

C. B-cells.

D. Macrophages.

E. Basophiles.

*Young woman with blood group A had suffered in road accident , and she was transfused with donor blood of group B by mistake. Posttransfusion reaction set up, leading mechanism of which is immunopathological reaction. Which type does it belong to?

Cytotoxic

Anaphylaxis

Immune complex

Cellular

Stimulating

51. A 54-year-old woman referred to a doctor with complaints of hen's eggs intolerance, which appeared recently. Antihistamines prescribed by the doctor slightly improved the status of the patient. What antibodies could provide the development of this reaction?

IgA.

IgE.

IgD

IgG.

IgM.

For detection of sensitivity to antibiotic patient is injected with 0.2 ml of penicillin solution intracutaneously. After 10 min hyperemia and edema appear in the site of injection. Which type according Cumbs-Jelly’s classification has this reaction belong to?

Anaphylaxis (phenomenon Auveri)

Cytotoxic

Delayed type of hypersensitivity

Reaction is like Artus phenomenon

Tuberculin type reaction

At flat repair woman suddenly has had bout of breathless with sensation of lack of air, difficulties with breathing out, dry cough and anxiety. Bronchial asthma has been diagnosed. Which allergy mediator causes such effects?

Histamine

Serotonin

Prostaglandin E

Interleukin I

Interleukin 6

*The woman, 40 years old, visited doctor with complains onto itching, reddening, burning sensation of the checks. Vanishing crème had been used 1 hour ago. Which type of allergy reaction of I group due to Combs and Jelly does patient have?

Quincke’s edema

Bronchial asthma

Anaphylactic shock

Urticaria

Pollen allergy

The worker of factory with 20 years record of work has had contact dermatitis of hands. Which type of immunological disorder does such illness belong to?

Delayed type of allergy

Primary immunodeficiency

Immediate type of allergy

B-cell immunodeficiency

T-cell immunodeficiency

*01* After some minutes of injection made for patient with tetanus breathless and frequent pulse appeared, blood pressure decreased. Which drug was the most probable reason of complication?

Sulfonamide

Donor gamma-globulin

Anatoxin (Toxoid)

Antibiotic

*Antitoxic serum

*04*,*06* After 8 days of antitetanus serum injection patient with contaminated wound of the foot has fever (38 С), joint pain, rash and itching. Blood assay demonstrated leucopenia and thrombocytopenia. Which type of allergy reaction arises in this case?

Delayed type of hypersensitivity

Cytotoxic

Anaphylaxis

*Immune complex

Stimulating

*07* The patient, female, 27 years old, had taken eyes drops, including penicillin. After some minutes she had itching and burning of body, edema of lips and eyelids, whistle cough; blood pressure started to decrease. Which kind of Ig takes part in such allergic reaction?

IgG and IgD

IgA and IgM

*IgE and IgG

IgM and IgG

IgM and IgD

*Woman had being suffered from pollen allergy for 25 years. The treatment had been made with desensitization method (periodic injection with small doses of allergens) and allowed to heal. What type of mechanism for inhibition of allergy was the most probable?

Accumulation of T-suppressors and IgG

Basophiles inactivation

Blockage of cellular histamine and heparin receptors

Formation of immune complex

Decreasing of complement concentration into serum