3. Sickle Cell Disease.

***) All of the following about sickle cell anemia are true, except:

1. More common in black

2. Increased incidence of salmonella osteomyelitis

3. Predisposes to auto-splenectomy

4. More susceptible to falciparum malaria

5. Sickle cell tract are usually asymptomatic

Answer: D* More susceptible to falciparum malaria

***) The following features may be found in an adult with sickle cell anemia, except:

1. Aseptic necrosis of bone

2. Massive splenomegaly

3. Chronic leg ulcers

4. Hematuria

5. Impaired ability to concentrate urine

Answer: B* Massive splenomegaly

***) All can be associated with Sickle Cell Anemia, except:

1. Vaso-occlusive crisis

2. Infection

3. Bleeding disease

4. Organ damage

5. Chest Syndrome

Answer: C* Bleeding disease

4. G6pd Deficiency.

***) All the following are oxidant stress which can cause hemolysis in patient with Glucose-6-phosphate dehydrogenase (G6PD) deficiency, except:

1. Infection

2. Sulfa drugs

3. Vit E

4. Fava beans

5. Nitrofurantoin

Answer: C* Vit E

***) Favism is a hemolytic anemia caused by deficiency of:

1. Pyruvate kinase

2. Glucose-6-phosphate dehydrogenase

3. Al-antitrypsin

4. Alanine aminotransferase

5. Acid phosphatase

Answer: B* Glucose-6-phosphate dehydrogenase

6. Macrocytic Anemia.

1. Vitamin b12 Deficiency.

***) All of the following are features of pernicious anemia, except:

1. Usually over 30 years, with blue eyes

2. Microcytic and hypochromic anemia

3. Subacute combined degeneration of the cord can occur

4. Dementia is a feature

5. Optic atrophy can occur

Answer: B* Microcytic and hypochromic anemia

***) All of the following about pernicious anemia are true, except:

1. Is a disease of elderly

2. Weight loss is a common feature

3. Subacute combined degeneration can occur

4. Gastric atrophy with achlorhydria

5. Treatment should be continued for two years

Answer: E* Treatment should be continued for two years

***) All of the following are causes of macrocytic anemia, except: Q2012

1. Vit B₁₂ deficiency

2. Folate deficiency

3. Hypothyroidism

4. Hyperthyroidism

5. Chronic liver disease

Answer: D* Hyperthyroidism

***) A macrocytic peripheral blood smear may be seen in any of the following, except:

1. Alcoholism

2. Hypothyroidism

3. Celiac disease

4. Folate deficiency

5. Iron deficiency

Answer: E* Iron deficiency

***) All of the following are causes of macrocytic anemia, except:

1. Vit B₁₂ deficiency

2. Chronic liver disease

3. Sickle cell anemia

4. Hypothyroidism

5. Folate deficiency

Answer: C* Sickle cell anemia

***) All of the following are causes of macrocytosis (large red cells), except:

1. Alcoholism

2. Hypothyroidism

3. Chronic renal failure

4. Sideroblastic anemia

5. Hemolysis

Answer: D* Sideroblastic anemia

***) All about vitamin B₁₂ are true, except:

1. It is a cobalt containing substance

2. Deficiency causes large primitive red cell precursors to appear in the peripheral blood

3. It is mainly absorbed in terminal ileum

4. It is bound firmly to intrinsic factor prior to absorption

5. It presents in high amount of vegetables

Answer: E* It presents in high amount of vegetables