C. Substitutes

Instead of a reverb, you can use multiple delays - I typically set one short and one longer. They mask the obviousness of each other and get you an ambient sound, but it's different from reverb. It may also consume less DSP.

Instead of a chorus, you can use a Pitch Glide with -/+ 0.1 Pitch for a similar detune effect. Also if you can't fit a mod effect but need a delay, you can use the Delay w/Mod delays. This is more subtle than a true mod effect, but it adds that aspect to your tone.

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D. Ordering

Effects that affect dynamics or distortion are sensitive to what is being sent into them, compared to non-dynamic effects. Be aware of how ordering effects matters, and experiment with each effect before or after a compression or distortion element. For instance, the whole section on distortion character was mostly about how the way a signal is EQ'ed impacts how distortion will operate. EQ before distortion sounds completely different from EQ after distortion. This equally applies to Wah pedals, phasers, choruses, and other effects. On the other hand, certain effects will operate virtually the same and have negligible impact on other effects independent of where it occurs in the effects chain, such as a pitch shifter.

The best advice is to experiment, but here are some general tips:

Noise Suppressors/Gates

The general consensus is to make this the first effect in your chain. There it will simply mask your pickup noise when you are not playing. It has the most impact on tone at the end of the chain but can lead to unnatural sounding cut-off on notes. An interesting place for it is after a compressor but before distortion. Sometimes you can use two on each side of a compressor/gain stage to tighten up how effectively it works. This is how Periphery gets their very punchy tone, going quickly from searing power chords to complete silence. For more on noise gates, see here.

Chorus/Phaser/Flanger

Generally, you get the expected swooshing sound behind your distortion phase, but placing it beforehand can give a very difficult to describe but interesting sound. I kind of like it in this position, because it has less of a swooshing sound to it, which I find detracts from the actual music. It also makes your distortion character change, which makes it a bit more interesting, especially if you're playing a very repetitive part, such as straight palm-muted single notes. I use mod effects in both positions.

EQ

As mentioned in the amp/tone page, EQ before distortion has a much larger effect on how the distortion operates than how the frequency response is changed. I generally use a single Studio EQ or Mid-Focus EQ to sculpt the distortion character, while I use multiple Parametric EQ's and/or a Mid-Focus EQ after distortion to dial in the desired frequency response in my final tone.

Delay/Reverb

I don't know how anyone gets away with putting delay before a distortion phase. The distortion will compress it and cause the delayed signal to be just as loud or nearly as loud as what you are currently playing, sounding like two guitars fighting for space, playing different things at the same time. People have said EVH put his delay in front his amp distortion, but I can't get it to sound right. I think they're wrong and his echoplex was being used for tonal changes, not actual delay.

I generally put my delay and reverb last (or close to last) in the chain. I don't think it matters which goes first. Occasionally I'll use two delays.

Pitch Shifters

(Octave, Whammy [Pitch Glide], Smart Harmony) - I like these in front my distortion phase usually. The whammy especially sounds more like a real whammy bar that way. Smart Harmony I like behind my distortion - then it sounds like you're playing with another guitarist or double-tracking it. When in front, it sounds more like you're playing double-stops. Experiment with the mix when pitch shifting, especially when you put it in front your distortion - low settings will subtly change your tone rather than sounding like you're adding another track at a lower volume.

Sorry if this section is a little light, but I'm not so much an effects guy. I focus on getting a good distortion sound, rather than layering up a bunch of effects.

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