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3. Hepatic jaundice (parenchymal)

REASONS: acute and chronic hepatitis, infectious mononucleosis, drug and alcoholic liver lesions, cirrhosis, hepatocellular cancer.

SYMPTOMS:

  1. Dull pain in the right hypochondrium, jaundice, unstable skin itching, general weakness. The skin is saffron yellow with a reddish tint, the liver is enlarged, tightened, often slightly painful, sometimes normal or reduced. Bradycardia

  1. Blood - hyperbilirubinemia, often due to both direct and indirect fractions of bilirubin, a decrease in prothrombin, an increase in the activity of transaminases (ALT, AST).

  1. Urine - dark, beer-colored, bilirubinuria, urobilinuria

  2. Feces - not changed or moderately discolored, the release of stercobilin is reduced.

  3. Instrumental techniques confirm liver damage.

4. Suprahepatic jaundice (hemolytic)

REASONS: congenital or acquired independent diseases (microspherocytic hereditary anemia, neonatal erythroblastosis, acute post-transfusion anemia), or a symptom of a number of diseases (croupous pneumonia, subacute septic endocarditis, Addison-Birmer disease, malaria, lung infarction, malignant tumors, some, or a consequence of toxic and drug damage (arsenic, hydrogen sulfide, phosphorus, sulfonamides).

SYMPTOMS:

  1. General weakness, decreased appetite.

  2. Jaundice without itching with a lemon-yellow tint and pallor of the skin.

  3. The liver is slightly enlarged, painless.

  4. The spleen is enlarged.

  1. In the blood, moderate hyperbilirubinemia, mainly due to free (indirect) bilirubin. Signs of hemolytic anemia. Coombs test is positive.

  1. The indicators ALT, AST are not changed.

  2. In the urine there is no bilirubin, but there is an increased amount of urobilin.

  3. The feces are dark, the content of stercobilin is increased.

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6. Cholestatic syndrome

  • stagnation and violation of the secretion of bile into the duodenum with the accumulation of its components in the liver and blood.

Allocate intrahepatic and extrahepatic cholestasis. CAUSES of extrahepatic cholestasis:

1. Stones of the main extrahepatic and main intrahepatic ducts;

2. Damage to the head of the pancreas (tumor, pancreatitis, cyst, abscess);

3. Stenosis and tumor of the large duodenal papilla;

4. Inflammation, tumors and strictures of the extrahepatic bile ducts;

5. Parasitic infections (opisthorchiasis, fascioliasis, ascariasis, clonorchosis, echinococcosis);

6. Enlarged lymph nodes in the gates of the liver;

7. Tumor and duodenal diverticulum. REASONS for intrahepatic cholestasis:

1. acute and chronic hepatitis;

2. Cirrhosis of the liver (especially primary biliary cirrhosis);

  1. Liver tumors, sarcoidosis, tuberculosis, lymphogranulomatosis, cholangitis, pregnant cholestasis, drug cholestasis.

SYMPTOMS:

  1. Itching, pigmentation and scratching of the skin;

  2. Jaundice, enlarged liver;

  3. Xanthomas, xanthelasms;

  1. With prolonged cholestasis - there may be visual disturbances in the dark, bleeding, bone pain (due to malabsorption of fat-soluble vitamins A, E, D, K);

  1. An increase in serum bilirubin (mainly associated), the activity of alkaline phosphatase, gamma-glutamine transferase, leucine aminopeptidase, the level of bile acids, cholesterol and its fractions, copper;

  1. A sharp decrease or disappearance of urobilin in the urine.

  1. Hepatolienal syndrome

REASONS: acute and chronic hepatitis and cirrhosis, acute and chronic leukemia, sepsis, collagenoses, pathology of the liver vessels, infectious diseases (malaria, leptospirosis). SYMPTOMS:

  1. Clinical and instrumental signs of hepatosplenomegaly.

  1. The detection of enlarged liver and spleen allows you to clinically differentiate the diseases associated with this syndrome. Often, it is accompanied by hypersplenism syndromes and liver damage.