- •Mistchenko V.P., Tkachenko e.V. Normal physiology
- •Dear students!
- •Lecture 1 (Introductional) Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Excitory tissues physiology. Excitive tissues functionning general features.
- •Lecture 2 Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Muscular contractions regimes.
- •Smooth muscles functional classification:
- •Receptors features:
- •Lecture 3 Nervous tissue physiology (receptors, nervous fibres, synapses).
- •2 Main receptors types:
- •Lecture 4 Different cns levels role in motor acts regulation Spine role in motor acts regulation.
- •2 Spine functions:
- •Stem role in motor functions regulation.
- •Diencephalon
- •Brain reticular formation
- •Cerebellum
- •Basal ganglions.
- •Locomotion neuronal organization.
- •Motor functions regulatory levels:
- •Lecture 5 Autonomic nervous system physiology and its role in functions regulation.
- •Lecture 6. Physiological functions humoral regulation. Interrelations between nervous and humoral mechanisms of physiological functions regulation in organism.
- •Hormones synthesis, secretion and releasing.
- •Interrelations between nervous and humoral mechanisms in physiological functions regulation.
- •Lecture 7. Sensor systems physiology (analizators and their significance for organism interrelations with surrounding external and internal environment).
- •Auditory analizator.
- •Conduction of sound from the tympanic membrane to the cochlea
- •The basilar membrane and resonance in the cochlea
- •Transmission of sound waves in the cochlea - the “travelling waves”
- •Corti organ functions
- •The auditory pathway
- •Visual analizator
- •Image formation on the retina
- •The visual pathways
- •Olfactory (smell) analizator
- •2 Main theories of smell:
- •Lecture 8 Organism integrative activity and behavioral physiological bases (the higher nervous activity, behavioral congenital and acquired forms, memory, thinking and speech).
- •Hereditary behaviour forms
- •Instincts organization
- •Acquired behavioural forms
- •Lecture 9. Human higher nervous activity peculiarities (emotions, motivations, the highest nervous activity types)
- •Stress and anger
- •Lecture 10 Waking state, sleep, dream and hypnosis.
- •Lecture 11. Blood circulation system. Heart physiology (cardiac activity phases, heart tones, electrocardiogram).
- •Complex p – atrial.
- •Lecture 12.
- •Vessels physiology. Blood pressure. Pulse. Capillary and venous circulation. Lymphatic supply. Functional vessels classification:
- •Vessels activity main indexes:
- •Pulse clinical characteristics main indexes:
- •Capillary circulation and its peculiarities
- •Venous circulation
- •3 Phlebogram waves:
- •Lymphatic circulation
- •Lecture 13 Blood circulation regulation. Heart-vascular regulation center. Blood circulation nervous and humoral regulation. Blood circulation regulation distinguishing features in separate organs.
- •Humoral-chemical regulation
- •Circulation regulation peculiarities in separate organs
- •Circulation in heart
- •Circulation in brain
- •Blood circulation in lungs
- •Lecture 14 Blood physiology – blood functions. Blood physico-chemical peculiarities. Erythrocytes and erythropoiesis.
- •Main blood functions:
- •Blood physical-chemical peculiarities and constants.
- •Erythrocytes Er (red blood cells rbc)
- •1. According to causative agent action:
- •2. According to localization:
- •Erythrocytes functions:
- •Erythropoiesis and its regulation.
- •Neural-humoral erythropoiesis regulation
- •Lecture 15. Protective blood functions connected with leucocytes. Blood groups.
- •Leucocytic formula:
- •Crossings.
- •Separate leucocytes physiology.
- •Leucopoiesis regulation.
- •Blood groups.
- •Lecture 16. Platelets (thrombocytes) physiology. Haemostasis (vascular-platelet and coagulational).
- •Platelets functions:
- •Thrombocytopoiesis regulation
- •Plasmatic blood coagulation factors.
- •Lecture 17. Anticoagulants and fibrinolysis.
- •Lecture 18.
- •Vascular-platelet haemostasis, blood coagulation and fibrinolysis regulation.
- •Lecture 19. Respiration physiology. External respiration. Gas transition and transfer by blood.
- •Oxygen transport.
- •Oxygen transfer conditions
- •Oxyhaemoglobine dissociation curve moving:
- •Carbon dioxide transport
- •Carbon dioxide forms
- •Lecture 20. Respiration regulation.
- •2) Reflexes from respiratory musculature proprioreceptors:
- •Lecture 21. Modern human being feeding (new approaches to the problem).
- •Modern feeding in childhood.
- •Lecture 22 Digestion, its types and functions. Oral cavity role in digestion.
- •Alimentary tract main functions:
- •Lecture 23 Digestion in stomach
- •Stomach secretion regulating
- •Lecture 24. Digestion in intestine. Absorbtion in alimentary tract.
- •Digestion in large intestine.
- •Lecture 25. Hunger, appetite and satiation state. Substance and energy exchange, thermoregulation.
- •Lecture 26. Excretion (separate organs and systems role). Kidneys functions.
- •Lecture 27 (Final). Healthy life style physiological bases.
- •In conclusion, telling “Good-bye” to you we would like to wish you following:
- •Content.
- •Lecture 1 (Introductional). Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Lecture 2. Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Lecture 3. Nervous tissue physiology (receptors, nervous fibres, synapses).
Vessels activity main indexes:
velocity,
pressure,
pulse.
Blood movements velocity types:
Volumetric velocity – blood amount flowing through transversal vessel section in time unit. It is expressed in ml/min and depends on pressure gradient at vessel beginning and end as well as on resistance to blood stream. Its size depends on organ state (for instance, in course of muscular activity this velocity increases in them in tens times). This velocity is determined by rheography method.
Linear velocity – distance which blood particle passes through time unit. It is determined in m/sec and is under norma:
in aorta – 0,5-1,0 m/sec,
large arteries – up to 0,5 m/sec,
in veins – 0,25 m/sec,
in capillaries – 0,05 m/sec.
Investigation methods: direct – stains and different substances introduction; indirect – ultrasound.
Circulation velocity – blood transport time on circulation circle. Norma: 14-20 sec.
Investigative methods: radioactive.
Blood pressure – force whith which blood presses onto vessel walls.
It depends on:
a) heart activity,
b) vessels resistance,
c) their diameter,
their length,
blood viscosity.
Maximal (systolic) pressure is registrated during heart systole. Its size is equal to 100-130 mm merc col (on brachial artery). There is a tendency to this pressure increasing during last years of practically healthy children even of school age. Its level depends mainly on heart activity.
Minimal (dyastolic) pressure is characterized by size registrated during dyastole. Norma: 65-90 mm merc col. Vascular wall tone is a dominant factor determining this pressure.
Pulse pressure – matematic difference between systolic and dyatolic pressure level. Its maximal size is in arteries near heart. The farther from heart the pressure pulse difference is decreased and beginning from arterioles it disappears.
Middle-dynamic pressure – expresses energy with which blood is moved, it provides blood movement through vessels and it is the average resulting size for all pressure fluctuations (oscillations) alongside all vascular system. Its level is less than systolic but more than dyastolic. Norma: 90-100 mm merc col.
Pressure changings in course of transport through all vessels:
aorta – 120-130 mm merc col.;
arteries – 100-120 mm merc col.;
arteries- 40-80 mm merc col.;
capillaries – 20-40 mm merc col.;
veins – 5-10 mm merc col.;
vena cava - up to 0 mm merc col.
Arterial pulse – or push, arterial wall fluctuation caused by systolic pressure increasing in arteries. Pulse wave appears in aorta when pressure is sharply increased in it and its wall is stretched. This wave is spread with velocity 3-15 m per second from aorta to arterioles. It may be registrated on large, superficially located arteries, by palpation or graphically (sphygmogram). At palpation its necessary to perform on both hands simultaneousely (hands must be at heart level) in one and the same patient location from initial investigation. If one can not determine any difference further pulse investigation should be performed on one hand (at pulse difference on both hands pulse is called different). Different pulse may be diagnostic sign of mitral valve stenosis, aortal aneurisme.
One can differentiate on sphygmogram:
anacrote (it corresponds to ventricles systole) – curve ascent (rising);
catacrote (it corresponds to blood slow exile from ventricules in its beginning, rest part – ventricules dyastole) – curve descent (falling down, drop);
dycrote – there is dycrotic ascent on catacrote, it corresponds to blood return to heart during dyastole ans its shock to semicircular valves.
