- •Mistchenko V.P., Tkachenko e.V. Normal physiology
- •Dear students!
- •Lecture 1 (Introductional) Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Excitory tissues physiology. Excitive tissues functionning general features.
- •Lecture 2 Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Muscular contractions regimes.
- •Smooth muscles functional classification:
- •Receptors features:
- •Lecture 3 Nervous tissue physiology (receptors, nervous fibres, synapses).
- •2 Main receptors types:
- •Lecture 4 Different cns levels role in motor acts regulation Spine role in motor acts regulation.
- •2 Spine functions:
- •Stem role in motor functions regulation.
- •Diencephalon
- •Brain reticular formation
- •Cerebellum
- •Basal ganglions.
- •Locomotion neuronal organization.
- •Motor functions regulatory levels:
- •Lecture 5 Autonomic nervous system physiology and its role in functions regulation.
- •Lecture 6. Physiological functions humoral regulation. Interrelations between nervous and humoral mechanisms of physiological functions regulation in organism.
- •Hormones synthesis, secretion and releasing.
- •Interrelations between nervous and humoral mechanisms in physiological functions regulation.
- •Lecture 7. Sensor systems physiology (analizators and their significance for organism interrelations with surrounding external and internal environment).
- •Auditory analizator.
- •Conduction of sound from the tympanic membrane to the cochlea
- •The basilar membrane and resonance in the cochlea
- •Transmission of sound waves in the cochlea - the “travelling waves”
- •Corti organ functions
- •The auditory pathway
- •Visual analizator
- •Image formation on the retina
- •The visual pathways
- •Olfactory (smell) analizator
- •2 Main theories of smell:
- •Lecture 8 Organism integrative activity and behavioral physiological bases (the higher nervous activity, behavioral congenital and acquired forms, memory, thinking and speech).
- •Hereditary behaviour forms
- •Instincts organization
- •Acquired behavioural forms
- •Lecture 9. Human higher nervous activity peculiarities (emotions, motivations, the highest nervous activity types)
- •Stress and anger
- •Lecture 10 Waking state, sleep, dream and hypnosis.
- •Lecture 11. Blood circulation system. Heart physiology (cardiac activity phases, heart tones, electrocardiogram).
- •Complex p – atrial.
- •Lecture 12.
- •Vessels physiology. Blood pressure. Pulse. Capillary and venous circulation. Lymphatic supply. Functional vessels classification:
- •Vessels activity main indexes:
- •Pulse clinical characteristics main indexes:
- •Capillary circulation and its peculiarities
- •Venous circulation
- •3 Phlebogram waves:
- •Lymphatic circulation
- •Lecture 13 Blood circulation regulation. Heart-vascular regulation center. Blood circulation nervous and humoral regulation. Blood circulation regulation distinguishing features in separate organs.
- •Humoral-chemical regulation
- •Circulation regulation peculiarities in separate organs
- •Circulation in heart
- •Circulation in brain
- •Blood circulation in lungs
- •Lecture 14 Blood physiology – blood functions. Blood physico-chemical peculiarities. Erythrocytes and erythropoiesis.
- •Main blood functions:
- •Blood physical-chemical peculiarities and constants.
- •Erythrocytes Er (red blood cells rbc)
- •1. According to causative agent action:
- •2. According to localization:
- •Erythrocytes functions:
- •Erythropoiesis and its regulation.
- •Neural-humoral erythropoiesis regulation
- •Lecture 15. Protective blood functions connected with leucocytes. Blood groups.
- •Leucocytic formula:
- •Crossings.
- •Separate leucocytes physiology.
- •Leucopoiesis regulation.
- •Blood groups.
- •Lecture 16. Platelets (thrombocytes) physiology. Haemostasis (vascular-platelet and coagulational).
- •Platelets functions:
- •Thrombocytopoiesis regulation
- •Plasmatic blood coagulation factors.
- •Lecture 17. Anticoagulants and fibrinolysis.
- •Lecture 18.
- •Vascular-platelet haemostasis, blood coagulation and fibrinolysis regulation.
- •Lecture 19. Respiration physiology. External respiration. Gas transition and transfer by blood.
- •Oxygen transport.
- •Oxygen transfer conditions
- •Oxyhaemoglobine dissociation curve moving:
- •Carbon dioxide transport
- •Carbon dioxide forms
- •Lecture 20. Respiration regulation.
- •2) Reflexes from respiratory musculature proprioreceptors:
- •Lecture 21. Modern human being feeding (new approaches to the problem).
- •Modern feeding in childhood.
- •Lecture 22 Digestion, its types and functions. Oral cavity role in digestion.
- •Alimentary tract main functions:
- •Lecture 23 Digestion in stomach
- •Stomach secretion regulating
- •Lecture 24. Digestion in intestine. Absorbtion in alimentary tract.
- •Digestion in large intestine.
- •Lecture 25. Hunger, appetite and satiation state. Substance and energy exchange, thermoregulation.
- •Lecture 26. Excretion (separate organs and systems role). Kidneys functions.
- •Lecture 27 (Final). Healthy life style physiological bases.
- •In conclusion, telling “Good-bye” to you we would like to wish you following:
- •Content.
- •Lecture 1 (Introductional). Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Lecture 2. Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Lecture 3. Nervous tissue physiology (receptors, nervous fibres, synapses).
Pulse clinical characteristics main indexes:
Freaquency – shocks (beats) amount per minute. Norma: 60-80 per minute (sometimes it is considered to 90). It may be estimated both on sphygmogram and by palpation.
Freaquent pulse (tachycardy, trachysphygmy) – it takes place at hyperthermia, in course of physical loading. At body temperature increasing on 1°C in adults pulse freaquency increases on 8-10 beats, in children – on 15-20 beats per 1 min.
Seldom pulse (bradycardy, bradysphygmy) – in sportsmen, in well-trained people.
Pulse freaquency is changing in course of ageing:
new-borns – 130-140 beats per min;
1 year – 120-130;
7 years – 90-100.
Rhythm – is determined both on sphygmogram and by palpation.
Rhythmical (regular) pulse – it is observed at equal spaces between pulse waves.
Arythmical (irregular) - it is observed at unequal spaces between pulse waves. Physiological arhythmias may be at intensive muscular loading, thermal procedures.
Pulse velocity – intensivity with which pressure in artery is increased during pulse wave arising and is reduced in course of its drop (it is determined the best on sphygmogram).
Rapid pulse - it may be in course of physical activity, aortal valve insufficiency.
Slow pulse – at faint, aortal ostium constriction.
Pulse altitude – is determined on sphygmogram.
High pulse -it is rapid or fast at the same time.
Low pulse – it is slow at the same time.
Pulse tension – vascular wall force or resistance degree to its pressure with fingers.
Solid pulse – pulse is accelerated and becomes stronger after vessel wall pressure. As a rule, it is observed at elderness due to vascular elasticity reducing; at hypertonic disease.
Soft pulse – pulse becomes slower and low-expressed after vessel wall palpation. It is under norma.
Diagnostic value: on tension degree one can tell about maximal blood pressure level. There is direct correlation between these 2 indexes.
Pulse filling – consists of pulse altitude and its tension. The higher systolic pressure plus blood volume and pulse altitude, the filling is stronger.
Full pulse.
Empty pulse – if pulse is small by its size, it is empty, as a rule.
Filliformis pulse – it is practically unexpressed - it is observed at strong bleeding, collaps and so on.
Capillary circulation and its peculiarities
Circulation in this part provides its main function – exchange between blood and tissues. That’s why main link in this system – capillaries – they are called exchangeable vessels. Thir function is tightly linked with vessels they are originated from - arterioles and vessels they come into (inflow) – venules. There exist direct arterio-venous anastomoses, connecting them out off capillaries. Mentioned vessels plus lymphatic capillaries are microcirculation system. This is main link of blood circulation system. Main reasons of diseases biggest part are in this region. Capillaries are the base of this system. Under rest state in norma only 25-35 per cent of them are opened, i.e. in working state; if more – one can see haemorrhagias and even organism death from internal bleeding, because blood is accumulated in capillaries and doesn’t reach heart.
Capillaries are located in intercellular spaces and that’s why metabolism occurs between blood and intercellular fluid.
Capillary exchange factors:
Hydrostatic pressure difference between capillary origin and its end (30-40 mm and 10 mm merc col correspondingly).
Low blood movement velocity (0,05 m/sec).
Filtration pressure (difference between oncotic pressure in intersticium and hydrostatic pressure in arterial capillary end – 15 mm merc col.). At its increasing – liquid comes into vessels and cellular dehydratation is developed.
Reabsorbtion pressure (difference between hydrostatic pressure in venous capillary end and oncotic pressure in intersticium – 15 mm merc col.). At its increasing – liquid (fluid) maily comes into tissues and oedemas are developed (for example, at proteins deficiency).
Capillary pulse (or Kwinke pulse) – pseudopulse, linked with rhythmical oscillations at small arteries dilation in course of ventricules systole. It is easily observed at thermal procedures: if one attaches mirror to lips small vessels pulsation is seen. But more often such pulse is pathology sign: aortal insufficiency, thyreotoxicosis.
