- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Analog registering devices
Registering devices are often used in medical electronics. They write down the information on any carrier. It allows to store, reuse, process and analyze the received medical and biologic information.
Displaying and registering devices are subdivided on analog - the continuous, discrete and combined, combining opportunities analog and discrete.
Analog registering devices are most widespread in practice of medical and biologic researches. Some of them are called recorders.
In medicine, biology and physiologies basically are used next ways of registration of the information on the carrier: drawing of a layer substances (dye); change of a condition of substance of the carrier: electrochemical, electrophotographic and magnetic record; removal of a layer of substance from the carrier: the smoked surface, thermal record.
T
he
elementary recorder is kymograph (fig.), working from the got spring,
or electrokymograph. Idea of kymograph - uniform rotation or moving
of a surface of the carrier. The recording devices used in medical
devices transform an electric signal in mechanical displacement. In
these devices the current which is passing on coils, cooperates with
a magnetic field of a constant magnet. As a result of this
interaction the mobile part deviates proportionally to force of a
current or an electric signal. The writing element leaving a trace on
the moving carrier of record is connected to a mobile part.
Except for the one-coordinate recorders fixing time dependence, in a research practice have was extended two-coordinate recorders.
I
n
a medical practice for fixation of the information the combined
devices, for example electron beam tubes are used still.
The device, principle of work of electrocardiograph.
The basic approaches
to registration of an electrocardiogram
Heart. An anatomic structure of heart.
Heart of the person - hollow muscular body. Heart is divided by continuous vertical partition on two half: left and right. The second partition going in a horizontal direction forms four cavities in heart: the top cavities are auricles, bottom - ventricles. The weight of heart of newborns is on the average equal 20 g. Weight of heart of the adult person makes 0,425-0,570 kg. The length of heart at the adult person reaches 12-15 cm, the cross-section size is 8-10 cm, anteroposterior - 5-8 cm. Weight and the sizes of heart increase at some diseases (heart diseases), and also at people, long time engaged the intense physical work or sports. The wall of heart consists of three layers: internal, average and external. The internal layer is presented by endothelium environment (endocardium), which covers an internal surface of heart. The average layer (myocardium) consists of a cross-section-striped muscle. The muscles of auricles are separated from muscles of ventricles by connective tissue partition, which consists of dense fibrous fibers - a fibrous ring. The muscular layer of auricles is developed more poorly, than a muscular layer of ventricles that is connected with features of functions, which each department of heart is carried out. The external surface of heart is covered by a serous membrane (epicardium) which is internal leaf of pericardial pleura - pericardium. Under a serous environment the largest coronary arteries and veins which provide blood supply of tissues of heart, and also the big congestion of nervous cells and nervous fibers, innervated heart are located.
The pericardium (cardiac shirt) surrounds heart as a bag and provides its free movement. The pericardium limits a stretching of heart to blood filling it and is a support for coronary vessels. It is possible to distinguish two kinds of valves in heart - atrioventricular and semilunar. Atrioventricular valves settle down between auricles and corresponding ventricles. Semilunar valves separate an aorta from left ventricle and a pulmonary trunk from right ventricle.
In activity of heart it is possible to allocate two phases: a systole (reduction) and diastole (relaxation). Duration of various phases of cardiac cycle depends upon frequency of cardiac reductions. At more frequent cardiac reductions activity of each phase decreases, especially diastole.
During diastole of auricles atrioventricular valves are opened also the blood acting from corresponding vessels, fills not only their cavities, but also ventricles. During a systole of auricles ventricles are completely filled with blood. Thus return movement of blood in hollow and pulmonary veins is excluded. By the end of a systole of ventricles pressure in them becomes more then pressure in an aorta and a pulmonary trunk. It promotes opening semilunar valves, and blood from ventricles acts in corresponding vessels. During diastole of ventricles pressure in them sharply falls, that creates conditions for return movement of blood aside ventricles. Thus, opening and closing of valves of heart is connected with change of value of pressure in cavities of heart.
The cardiac muscle possesses the next properties: excitability, ability to spend excitation and contractility.
Cardiac muscle is less excited, than skeletal. For excitation of cardiac muscle it is necessary to apply stronger irritation, than for skeletal. It is established, that the size of reaction of a cardiac muscle does not depend upon force of irritations (electric, mechanical, chemical). The cardiac muscle is as much as possible reduced both on threshold, and to stronger on size irritation.
Conductivity. Waves of excitation are spent on fibers of a cardiac muscle and a so-called special tissue of heart with unequal speed. Excitation on fibers of muscles of auricles extends with a speed of 0,8-1,0 m/sec, on fibers of muscles of ventricles - 0,8-0,9 m/sec, on a special fabric of heart - 2,0-4,2 m/sec.
Contractility. Contractility a cardiac muscle has the features. The first reduce muscles of auricles, then - papillary muscles and a layer of muscles of ventricles. In the further reduction covers also an internal layer of ventricles, providing movement of blood from cavities of ventricles in an aorta and a pulmonary trunk. Physiological features of a cardiac muscle is extended refractory period and automatism.
