- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Current of a liquid on a pipe of variable section and branched out
S
peeds
of current of a real liquid in a horizontal pipe of variable section
on various sites of a pipe differ also gradients of pressure
accordingly differ.
For liquids, with small viscosity, current can differ at low speeds and average levels of pressure differ too (rule Bernoulli). Besides in places of change of section of a pipe the turbulences causing significant losses are formed. Therefore usually static pressure along all pipes of variable section falls and more abruptly on sites of smaller section. The gradient of pressure depends on the general section of the branched out part in the branched out pipe. Under the formula of Newton force FB of internal friction is proportional to a gradient of speed in a direction of radius of a pipe. The gradient of speed, as shown in figure, has the greatest size near the wall of pipe and the least in its central part. Hence, force of internal friction and losses of energy of a liquid in layers, there are near the wall of pipe, considerably above, than in central. Therefore, if to compare the general losses of energy on internal friction in a continuous pipe and in branched out (at identical general section) it will appear, that in the latter case when the general surface is more than layers, there are near the wall of pipe, these losses considerably above.
It
follows as well from formula Gagen-Puazal,
according to
which
hydraulic
resistance in inverse proportion to
the
fourth
degree
of radius of a pipe. By simple transformations of this
formula
it is possible to show, that for the branched out pipe consisting
from
п
pipers,
resistance to current of a liquid at identical general
section
and
other equal conditions will be in
п
times
more in comparison
with
not branched out pipe. Accordingly in
п
time
increases also a gradient of pressure.
Definition of speed of blood-groove
There are some methods of definition of speed of a blood-groove. We shall consider physical bases of two of them. The ultrasonic method (ultrasonic flowmeter survey) is based on Doppler’s effect. The signal from the generator 1 of electric fluctuations of ultrasonic frequency acts on a radiator of ultrasound 2 (look figure) and on the device of comparison of frequencies 3. The ultrasonic wave 4 gets into a blood vessel 5 and is reflected from moving erythrocytes 6. The reflected ultrasonic wave 7 gets in the receiver 8 where it will be transformed to electric fluctuation and amplifies. The strengthened electric fluctuation gets in the device 3. Here the fluctuations, the falling and reflected waves are compared, and is allocated Doppler shift of frequency in the form of electric fluctuation: U=Uocos2πνDt
From
this formula it is possible to define speed erythrocytes:
In large vessels speed erythrocytes depends on their arrangement concerning an axis: erythrocytes, located close to an axis, move with greater speed, and erythrocytes located close to a wall of a vessel move with smaller speed. The ultrasonic wave can be reflected from different erythrocytes; therefore Doppler shift has an interval of frequencies. Doppler’s effect allows to define average speed of a blood-groove and speed of movement of various layers of blood.
The
electromagnetic method (electromagnetic flowmeter survey)
measurements of speed of a blood-groove is based on a deviation of
moving charges in a magnetic field. Blood is electrically neutral
system, it consists from positive and negative ions. Hence, moving
blood is a stream of the charged particles which move with a speed
v.
Force in a magnetic field with induction B
acts on a moving electric charge q.
F=qvВ
If a charge negative, force is directed to opposite of vector product vВ.
The forces operating from a magnetic field on opposite charges are directed to the opposite parties. The positive charge accumulates about one wall of a blood vessel, about another - negative. Redistribution of charges on section of a vessel will cause occurrence of an electric field. This physical phenomenon refers to effect of the Hall.
Pressure
UH
(Hall’s pressure) depends on speed v
of
movements
of ions, i.e. from speed of blood. Thus, measuring this pressure, it
is possible to define and speed of a blood-groove. Knowing section
S
of a vessel, it is easy to calculate volumetric speed of a
blood-groove: Practically it is more convenient to use in this method
a variable magnetic field (see fig.). It leads to occurrence variable
Hall’s pressure UH
which then amplifies and measured.
