- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Tomographic methods
Tomography - a method of not destroying level-by-level research of internal structure of object by means of its repeated show through in various crossed directions.
Tomography - a method of radiological research by means of which it is possible to make a picture of the layer lying on certain depth of investigated object. Reception of a level-by-level picture is based on moving of two of three components (an x-ray tube, an x-ray film, object of research). Method at which the investigated object is motionless, and the x-ray tube and the cartridge with a film in coordination move in opposite directions were received wide distribution.
At synchronous movement of a tube and the cartridge only the necessary layer turns out precise on a film because only its contribution to the general shadow remains motionless concerning a film, all rest - is greased, almost not preventing to spend the analysis of the received image. Now the share of last method in researches promptly decreases, it gives not enough information and bears high beam loading to the patient. The given method has received the name a classical tomography or a linear tomography.
The main difference of methods of echosounding from a tomography consists that at echosounding are visualized borders and not areas (usually parameter of refraction)
Calculable tomography - area of mathematics which develops mathematical methods and algorithms of restoration of internal structure of object on projective data.
Computer tomography - a synonym of the term a tomography (all modern tomographic methods are realized by means of computer technics); the synonym of the term a x-ray computer tomography, this method has begun a modern tomography.
The anatomic tomography - is based on reception of cuts of tissues of the person with their subsequent fixing by means of chemical substances and their registration on a photofilm. Classical examples of an anatomic tomography are images of histologic preparations. Terminologically, now, the given methods do not carry to a tomography, by virtue of their destroying character.
Classification of kinds of a tomography.
Interposition of a source of probing radiation, bject and the detector.
From the point of view of interposition of a source of probing radiation, object and the detector tomographic methods can be divided into following groups:
Transmission - the probing external radiation which has been last through passive (not radiating) object is registered, being partially weakened thus;
Issue - the radiation leaving active (radiating) object with some spatial distribution of sources of radiation is registered;
Combined transmission-issue (luminescent, acoustic and optical) - secondary radiation from the sources distributed on volume of object and raised by external radiation is registered;
Echosounding - the probing external radiation reflected from internal structures of passive object is registered.
The sizes of investigated objects:
Microlevel (microtomography) - objects with size as separate cell are investigated
Level of objects, commensurable with a human body (from separate body or the laboratory mouse till the airplane)
Macrolevel - the atmospheric phenomena (clouds, cyclones, a tornado), planets and stars.
It is possible allocate by sphere of application:
Medical tomography (as a kind of medical visualization and medical diagnostics);
Industrial (technical) tomography (as a kind defectoscopy);
Tomography of macroobjects.
Probing radiation.
Tomography with use of sound waves (including seismic):
Ultrasonic tomography;
Seismic tomography
Tomography with use of electromagnetic radiation:
Issue tomography (scale-radiation);
One-photon issue tomography
Two-photon issue tomography
X-ray tomography; X-ray computer tomography
Optical (laser) tomography
Tomography in a radio range.
Tomography with use of electromagnetic fields:
magnetic-resonant tomography (MR-tomography)
Electro-impedance tomography.
Tomography with use of elementary particles:
Neutron tomography
Electronic tomography;
Proton tomography.
For tomographic methods the similar hierarchy can be presented as:
Two-dimensional tomography: it is a lot of foreshortenings from one plane - a set of one-dimensional projections plus mathematical processing - the 2D-tomogram
Three-dimensional level-by-level tomography: it is a lot of foreshortenings in set of parallel planes - a set of one-dimensional projections plus mathematical processing - a set of 2D-tomograms - the 3D-tomogram
Three-dimensional any tomography: it is a lot of foreshortenings in set of crossed planes - a set of one-dimensional projections plus mathematical processing - the 3D-tomogram
We receive distribution of some physical characteristic (areas of points of easing are restored). One foreshortening gives not enough information, therefore there is a necessity in repeated просвечивании in various crossed directions.
