- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Biophysical features of arterioles of the big circle of blood circulation.
Blood flows from arteries of elastic type in the resistive vessels possessing smoothly-muscular cells, which being reduced, actively change a gleam of vessels. Hemodynamic resistance is adjusted so. Volumetric speed of a blood-groove and a blood pressure in bodies depend from hemodynamic resistance. Hence, resistive vessels are the major regulators of hemodynamic. Typical representatives of arteries of muscular type are arterioles of the big circle of blood circulation. Arteries with diameter from ten up to hundred microns have such name. They have the general structural attribute - presence expressed smoothly-muscular environments.
The powerful muscular environment causes the basic functional property of arterioles - an active vascular tone. It is controllable tonic reduction of smoothly-muscular cells of a vascular wall. Changes of a vascular tone lead to narrowing or expansion of a gleam of arterioles and, hence, render the expressed influence on hemodynamic resistance. Due to an active vascular tone arterioles most effectively carry out the basic functions of arteries of muscular type: 1) maintenance of the certain level of a blood pressure in system of blood circulation; 2) redistribution of blood between bodies depending on need for it of each of them.
The basic means of sufficient delivery of blood to all bodies which at present require it, serves maintenance of superfluous pressure in system of blood circulation. It allows to change essentially volumetric speed of a blood-groove, managing rather a small amount of blood (the weight of blood at the person makes 1/13 part of weight of a body). Thus, arteries of muscular type are intended for maintenance in system of blood circulation of such superfluous pressure which provides reliable redistribution of blood between bodies in any conditions. Therefore аarterioles on their functional purpose can be assimilated to a water tower - they create maintenance of a blood pressure in an arterial channel. Infringement of this function of arterioles leads to a collapse (to a heavy faint with loss of consciousness at sharply developing vascular insufficiency which expression is first of all falling of a blood pressure). Thus, smoothly-muscular cells of arterioles of the big circle predetermine work, which heart should make (a myocardium of left ventricle) to overcome the general peripheral resistance of vessels.
The second function of arteries of muscular type - redistribution of blood between organs depending on need for it - is provided with work arterioles as «vascular cranes». From Puasal’s equation follows, that depending on a gleam of arterioles volumetric speed of a blood-groove in organ, to which they belong, and its changes are proportional to changes of radius of this gleam in the fourth degree.
Due to change of a tone of arterioles, being skeletal muscles, volumetric speed of a blood-groove in them increases at physical work in some tens times. Redistribution of blood between internal organs and a skin is connected with regulation of a vascular tone. Even within the limits of one body there is continuous «a game of vessels»: one arteriole is narrowed, others - extend. As a result the weight of blood in different sites of body is constantly redistributed. So the best blood supply at a minimum level of work of a cardiac muscle is reached. The greater role in development of some pathological processes belongs by arterioles.
The basic hardware of medical introscopy.
Introscopy
Introscopy - (intro - inside) not destroying research of internal structure of object and processes proceeding in it by means of sound waves (including ultrasonic and seismic), electromagnetic radiation of various ranges, a constant and variable electromagnetic field and streams of elementary particles.
Spheres of application
Medical diagnostics - medical introscopy or medical visualization
Defectoscopy- industrial (technical) introscopy.
Introscopy of macroobjects.
The basic methods
It is possible to allocate three basic kinds of introscopy methods:
Projective - reception of the shadow image of object;
Tomographic - reception tomographic images of object;
Echosounding, including Doppler’s echosounding.
Projective methods
In projective methods sounding (irradiation) of object from some foreshortening and receive its shadow image (projection) is spent. X-ray radiation (rontgenography) is used as probing radiation more often. It is possible to allocate methods with use of optical radiation, for example:
sorting of oranges: «with stays» and «without stays», sorting of eggs.
Projective methods work by a principle «one foreshortening - one picture». Thus for reception of the image mathematical transformations are not spent, post-processing is made only (adjustment of brightness-contrast, segmentation). It is possible to apply tomographic algorithms of reconstruction and to receive not shadow, and tomographic images at increase in quantity of foreshortenings and, accordingly, quantities of pictures.
Thus, the hierarchy of complication of projective methods can be presented as follows:
One foreshortening - one shadow image (a two-dimensional projection);
Set of foreshortenings - a set of shadow images;
Set of foreshortenings plus mathematical processing - the three-dimensional tomogram (a set tomographic images) - three-dimensional distribution of some physical characteristic.
