- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Rhythm of heart. Parameters of cardiac activity.
Rhythm of heart is the quantity of reductions in 1 minute, depends mainly on a functional condition of wandering and sympathetic nerves. At excitation of sympathetic nerves frequency of cardiac reductions increases. This phenomenon is called a tachycardia. Frequency of cardiac reductions decreases at excitation of wandering nerves. This phenomenon is called a bradycardia. A condition of a cerebral cortex influences on the rhythm of heart: at strengthening braking the rhythm of heart is slowed down, at strengthening exciting process is stimulated. The rhythm of heart can change under influence humoral influences, in particular temperatures of blood, affluent to heart. In experiences it has been shown, that the local irritation by heat of area of the right auricle (localization of the leading unit) conducts to increase of a rhythm of heart, at cooling this area of heart the opposite effect is observed. The local irritation by heat or a cold of other sites of heart is not reflected on frequency of cardiac reductions. However it can change speed of carrying out of excitation on conductive system of heart and to be reflected on force of cardiac reductions. Frequency of cardiac reductions at the healthy person is in dependence from age. These data are presented in the table.
Age |
Quantity of cardiac reductions in 1 minute |
Newborns |
120—140 |
Up to 5 |
130 |
5—10 |
88 |
10—15 |
78 |
15—60 |
68—72 |
Parameters of cardiac activity. Parameters of work of heart are systolic and minute volume of heart. Systolic or shock volume is the quantity of blood, which heart throws out in corresponding vessels at each reduction. The size of systolic volume depends on the sizes of heart, a condition of a myocardium and an organism. At the adult healthy person at condition of relative rest systolic volume of everyone ventricle is equal to approximately 70-80 ml. Thus, at reduction ventricles 120-160 ml of blood moves in arterial system. The minute volume of heart is a quantity of blood, which heart throws out in a pulmonary trunk and an aorta for 1 minutes. Average minute volume is 3-5 litres. Systolic and the minute volume of heart characterizes activity of all device of blood circulation.
External displays of activity of heart.
There are data on which the doctor judges about work of heart by external displays of its activity. It is a top push, cardiac tones. Top push. During a systole ventricles heart makes rotary movement, turning from left to right. The top of heart rises and presses on a thorax in the field of the fifth intercostal interval. During a systole heart becomes very dense; therefore pressing of a top of heart on an intercostal interval can be seen (bulging, protrusion). The top push can be probed (to palpate) and to define its borders and force. Cardiac tones are the sound phenomena arising in working heart. It is possible to distinguish two tones: I-systolic and II - diastolic.
Systolic tone. Atrioventricular valves take part in an origin of this tone. During a systole ventricles atrioventricular valves are closed, and fluctuations of their shutters and attached to them tendinous strings cause I tone. Besides the sound phenomena which arise at reduction of muscles ventricles take part in origin I of tone. On sound features I tone is lingering and low.
Diastolic tone arises in the beginning diastole of ventricle during protodiastolic phase, when there is a closing of semilunar valves. Fluctuation of shutters of valves thus is a source of the sound phenomena. Under the sound characteristic II tone is short and high.
Also it is possible to judge about work of heart on the electric phenomena arising in it. Them are called biopotentials of heart and receive by means of electrocardiograph. They carry the name of the electrocardiogram.
