- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Devices for measurement of function of external breath
Recently research of function of external breath both at patients with a pulmonary pathology, and at healthy at carrying out surveys finds the increasing application with a view of revealing and differential diagnostics of illnesses of bodies of breath, and also for an estimation of efficiency of treatment and examination of work capacity. Used earlier in practice of doctors of cabinets of functional diagnostics spirograph enabling to diagnose a pathology at a level only large bronchial tubes, give a up the place to more perfect devices, allowing to define the forced volumetric speed of a breath on curve "stream-volume", to carry out research and to spend processing in the automated mode of the received parameters of breath.
The store
on replaceable magnetic disks provides long-term storage of results
of inspection. The last can be written down also from the external
computer connected with a spirometer. Measurements and calculations
can be recorded on a usual paper with use of the printer. The program
stipulates co
mparison
of data of research of function of external breath of the patient to
due sizes of corresponding parameters
The program of management of work of a spirometer automatically tests electronic units of a spirometer, by means of the operator spends measurements, automatically calculates parameters of breath, analyzes correctness and reliability of results, spends comparison with due (normative) parameters on the several widespread systems, gives out imprisonment before trail, provides long-term storage of results in archive. The software can easily change according to requirements and wishes of the user.
Presence of the universal processor device, the multikeyboard keyboard, the display with good resolution, printers allows to apply a spirometer as a personal computer in practical work of the doctor, and also to spend scientific calculations, statistical processing of results of researches. During research the respiratory stream of air passes through the measuring device, then again gets in an atmosphere.
The computer receives the signal of a measuring head preliminary transformed to the digital form in the module of interface, processes it, defines parameters of breath, and also visualizes on the display in a mode of " real time " that allows the operator to supervise process of measurement.
By comparison of data of the control and domestic devices describing various parameters of ventilating ability of lungs at surveyed patients, it has appeared, that available distinctions are not authentic and are within the limits of numerical values for the given pathology.
Thus, on the basis of the lead researches it is established, that a spirometer “МАС-1” on the parameters of function of external breath specified above, and also under the form curve "stream-volume" correctly reflects character of a pathology in bodies of respiratory system and the clinical diagnosis of disease.
In summary it is necessary to note, that the domestic spirometer “МАС-1” is compact, simple and convenient in work, by it branches pulmonology structure and cabinets of functional diagnostics of poly clinics can be carried out.
S
pirograph-
СП-3000
The diagnostic computer medical device intended for research of function of external breath at adults and at children. It can be used in polyclinics, hospitals, clinics, and also in research and other medical institutions.
Possible scopes of spirograph: research of function of external breath in practical medical work and in scientific researches both in out-patient, and in stationary conditions, forecasting of current of pulmonary diseases, preoperative inspection and an estimation of a degree of operational risk, inspections, medical labour examination, sports medicine, professional illnesses, the control of efficiency of medical and rehabilitation actions, an asthma-monitoring, individual selection of medicines.
S
pirograph
СМП-21
Microprocessor computer - effective system for check of
functions of lungs, allows to define also active resistance of lungs.
Scope:
Branches of functional diagnostics;
The control of efficiency of medical and rehabilitation actions over pulmonology;
Asthma-monitoring;
Sports, aerospace medicine;
Medical labour examination.
Measurement 21 parameters of ventilating function of lungs on a breath and an exhalation;
Display of results on graphic display with a conclusion to the printer; Automatic calculation norms of the patient; formation of imprisonment before trail;
Data storage of 30 patients in volatile memory;
Opportunity of carrying out of inhalation tests;
Opportunity of application in stationary and out-patient conditions
D
evices
of artificial ventilation of lungs SLE-2000 is intended for carrying
out of operated artificial ventilation of lungs at newborns and
children during carrying out reanimation actions in conditions of
clinical hospitals, maternity hospitals, scientific research
institutes of a children's structure. The device can be completed, a
dampener, a respiratory contour the monitor, the compressor.
Research of rheological properties of biological liquids.
Methods of research of blood circulation.
Rheography.
Equation of Bernoulli. Static and dynamic pressure.
The liquid incompressible and not having internal friction or viscosity is called ideal liquid.
Current of a liquid is called stationary or established if speeds of particles of liquid in each point of a stream in due course do not change. The established current characterizes lines of a current - the imagined lines conterminous with trajectories of particles. The part of a stream of the liquid, limited from different directions lines of a current, forms a tube of a current or a jet. We shall allocate a tube of a current so narrow; it is possible to consider speeds of particles V are identical in its any section S perpendicular axes of a tube, on all section.
Then the volume ΔV of a liquid proceeding through any section of a tube in unit of time remains to constants, as movement of particles in a liquid occurs only along an axis of a tube: ΔV =vS=const. This parity is called a condition of indissolubility of a jet.
From here
follows, as for a real liquid at the established current on a pipe of
variable section quantity Q of the liquid
proceeding
in
unit of time through any section of a pipe, remains to constants
(Q
= const) and average speeds of current in various sections of a pipe
inversely proportional to the areas of these sections:
Let's allocate in a stream of an ideal liquid a tube of a current, and in it - small enough volume of a liquid ΔV in mass Δm, which at current of a liquid moves from position A to position B.
speed
and
are at height
h1
from
a zero level; in position
B
-
accordingly
.
Sections
of a tube of a current accordingly
S1
and
S2.
The
liquid which is being under
pressure, possesses internal
potential energy (energy
of pressure), and can make
work. This energy
Wp
is measured by product of pressure
upon volume
V
of a liquid
In this
case moving of mass
of
liquid occurs under action of a difference of forces of pressure in
sections S1
and
S2.
Work
made at it Ар
is equal to differences potential energies
in
points A
and B:
.
This
work is spent for work on overcoming gravity
and on change of kinetic energy of mass
liquid
Hence,
Positions A and B are chosen any way, therefore it is possible to approve, that in any place of a tube of a current the condition is kept
Having
divided this equation on
,
we shall receive
Where
— density
of a liquid.
I
t
is equation Bernoulli.
All
members of the equation,
have
dimension of pressure and refer to:
static:
hydrostatic:
-
dynamic. Then
equation
Bernoulli
it
is possible to formulate so:
Full
pressure equal to the sum of static, hydrostatic and dynamic
pressure, remains in size of a constant in any cross-section section
of a stream at stationary current of an ideal liquid. Hydrostatic
pressure
remains
to
constants and can be carried in the right part of the equation
which
thus becomes
for
a horizontal tube of a current
Static pressure causes potential energy of a liquid (energy of pressure), dynamic pressure - kinetic.
From this equation the conclusion, which is called the rule Bernoulli follows:
Static pressure of a nonviscous liquid at current on a horizontal pipe increases there where its speed decreases and on the contrary.
It is possible to show it, for example, passing the tinted water on enough wide pipe of variable section and comparing levels of a liquid in manometrical tubes on various sites of a pipe. It is possible to pick up conditions, at which pressure of a liquid (or gas) in the narrowed site of a pipe becomes less atmospheric and then the jet in this place can have soaking up an effect. Such effect is applied in the water-jet pump. The water-jet pump is silent and hygienic. Therefore it is often applied in a medical practice, for example at removal liquids from a cavity of pleura.
