- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Full resistance (impedance) of tissues of the organism Physical bases of rheography
Biological objects are characterized active and jet resistance. Total resistance of objects is called impedance. Tissues of an organism spend not only constant, but also an alternating current. In an organism there are no such systems which would be similar to coils of inductance; therefore its inductance is close to zero. Biological membranes and, hence, all organism possess capacitor properties, the impedance of tissues of an organism is defined only ohmic and capacitor resistance. Ohmic and capacitor properties of biological tissues can be modeled, using equivalent electric schemes. We shall consider some of them. For the scheme represented on fig. and, frequency dependence of impedance at
L = 0:
The equivalent electric schemes (fig. a, b) have a divergence with experience. Biochemical fabrics have resistance at greater frequencies. The equivalent electric scheme, combining first two model (fig. c) is most successful. Frequency dependence of impedance allows estimating viability of tissues of an organism that it is important to know for change (transplantation) tissues and bodies. In a dead tissues of a membrane desolate and the tissues possesses only ohmic resistance. Distinction in frequency dependences impedance turns out and in cases of healthy and sick tissues.
The impedance of tissues and bodies depends upon them physiologic conditions. The impedance changes depending on a condition of cardiovascular activity at filling of blood vessels.
The diagnostic method based on registration of change of an impedance of fabrics during intimate activity, is called rheography (impedance- plethysmography).
By means of this method rheogram of a brain (rheoencephalography), hearts (rheocardiogram), the main vessels, lungs, a liver and extremities turn out. Measurements are usually are made on frequency 30 KHz.
Rheography is applied in diagnostics of a various vascular infringements of a brain, extremities, lungs, hearts, and a liver. Rheography of extremities is used at diseases of the peripheral vessels, accompanied by changes of their tone, elasticity, narrowing or full corking of arteries. Record rheogram is made from both symmetric sites of extremities, on which electrodes are imposed with identical area and width is equal to 1020 mm.
Rheoencephalography
(REG) defines a tone and elasticity of vessels of a brain, measuring
their resistance to a current of high frequency at small values of
force of a current and voltage. It allows to define also filling of
parts of a brain by blood, to diagnose character and localization of
its defeats, gives good result at vascular diseases, especially at a
cerebral atherosclerosis. In the sharp period of an insult it helps
to establish ischemic character of frustration of blood circulation
or inopectic cerebellar infarction. Rheoencephalography
is perspective at traumas of a brain, its tumours, epilepsy, and
migraines.
Opportunities of rheograph "Credo":
- Rheoencephalography, rheogram of the upper extremities and lower extremities, automatic measurement of parameters of wave and calculation rheographic indexes.
- Delivery on the screen or the printer of results of analysis REG in a text kind in view of age of the patient, the preliminary diagnosis and results of previous inspections.
