- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Current of a liquid on a horizontal pipe. Puazal’s law.
Let's
consider
current
of a viscous, moistening wall of a liquid on a horizontal
pipe
of constant section therefore, it is important for understanding of
process of movement of blood on vessels. At rather low speed
current
thus has laminar character: the layer of molecules,
adjoining
to
a wall of a pipe, sticks to it and remains motionless.
Following
layers
of molecules under action of force
of
pressure and at counteraction of force
of
internal friction between layers it is displaced rather a
previous
layer
and moves
in
relation to walls of a pipe with some small speed. Each
subsequent
layer of molecules, mixing up
concerning
the
previous layer, moves
in
relation to
a
wall of a pipe with
gradually
increasing
speed
which
reaches
the
greatest value in the center of a pipe.
The mathematical analysis of this phenomenon shows, that distribution of speeds on section of a round pipe has parabolic character
The maximal speed in the center of a pipe
.
In these
formulas:
— pressure in the beginning and in the end of a site of a pipe in
length
- factor of viscosity of a liquid, R
-
radius of a pipe and r
-
radius of a considered layer of liquids.
Gradient of speed, on absolute size equal
,
gradually decreases and addresses
in
a zero on an axis of a pipe.
L
aminar
current
is established in pipes with smooth walls, without sharp changes of
the area of section or bends of a pipe, and as
at
absence of plural branching. At infringement of these
conditions
and especially at high speeds current passes in turbulent: speeds of
particles of a liquid thus vary randomly, formed
local
turbulences - there is a mixing of
particles
of a liquid.
For turbulent current local changes of pressure in the liquids causing oscillatory movement of particles, accompanied the sound phenomena (noise, murmur, etc.) owing to which turbulent current is easily found out are characteristic. Turbulent current is connected with additional expenses of energy at movement of a liquid, therefore in blood system it can lead to additional loading on heart. Noise arising at turbulent current of blood, can be used for diagnostics of diseases. At defeat of valves of heart there are the so-called intimate noise caused by turbulent current of blood. Turbulent current of blood in an aorta can be caused, first of all, by turbulence of a blood-groove in an input in it: whirlwinds of a stream exist, when blood is pushed out from ventricle in an aorta. At places of a branching of vessels, and also at increase of speed of a blood-groove current can become turbulent in arteries. Turbulent current can arise in a vessel in the field of its local narrowing, for example, at formation of a blood thrombus.
Speed
(critical
speed) of transition of laminar current in turbulent it is possible
to define, using the criterion certain from experience -
Reynolds's
Re
number
(dimensionless
size) which connects it with density
,
viscosity of a liquid
and diameter
D
of
a pipe:
.
If
Re ≤ 1000, then the current is laminar,
if Re > 1000, that
current
is turbulent.
Current
of blood on vessels depends upon its viscosity. Current of blood can
be laminar or turbulent. Laminar current of blood creates smaller
loading on heart as at it work of heart is directly proportional to
volumetric speed of a blood-groove, at turbulent movement of blood
between these parameters almost square-law dependence is established
(А~
Q1,8)
.
At current of a real liquid on a horizontal pipe potential energy of its particles is spent for work on overcoming internal friction and consequently static pressure along a pipe gradually falls. To provide current of a liquid, it is necessary to create the pressure a little bit exceeding pressure drops along all pipe in the beginning of a pipe. In a pipe of constant section pressure falls in regular intervals. If to connect levels of a liquid in the manometrical tubes established along a pipe, the direct line will turn out. (fig). If it to continue up to the basic vessel A it will divide height h a column of a liquid in a vessel on two parts h1 and h2.
The
height
h1
corresponds
to initial static pressure
,
height
h2
-
to dynamic pressure
causing speed
of
current of a liquid. The
tangent
of
a corner of an inclination of this straight line
characterizes
a gradient of pressure
(pressure
drop on unit
of
length of pipe):
.
Puazal
has established, that average speed
of
laminar
current of a liquid on to rather narrow horizontal round pipe of
constant section
it is directly proportional to a difference of pressure
at
an input and an output from
a
pipe, to a square of radius
R
of
a pipe and inversely proportional to length l
pipes and to factor of viscosity
of liquid (law
Puazal
);
Average
speed
of
current of a liquid defines the quantity of liquid
Q
proceeding through cross-section section S of a pipe in unit of time:
Hence,
This formula also name usually formula Gagen - Puazal. It can give and such kind:
,
where
Value ω is called hydraulic resistance.
