- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Interaction of X-ray radiation with substance.
Radiation is partially reflected from a surface at falling R-rays on a body. The basic part of radiation is absorbed, photons of x-ray radiation cooperate with electrons and atoms of molecules of substance passing through a body. Thus occurs:
1. Coherent dispersion;
2. Photoeffect
3. Kompton - effect
1
.
If
-
coherent
(classical)
dispersion
takes place (Аexit
- work of an output electron from substance). The direction of
movement of photons changes owing to influence of photons with
electrons the internal level, strong connected with a nuclear. Energy
and length of a wave remain constant. It does not cause biological
action.
2. If
the photon is absorbed, electron comes off atom: the substance is
ionized (substance turns to a positive ion), the photoeffect
occurs.
3. If
,
then
where The part of energy of a photon is spent for fulfillment of
work for an output of electron from the substance, other part is
spent for kinetic energy free electron, the third part is radiated in
the form of secondary radiation (
),
which dissipates in every possible directions.
Secondary radiation with length of a wave more, than length of a wave of excitation and with smaller energy is formed. This phenomenon is not coherent dispersion or Kompton-effect. Secondary radiation dissipates in every possible directions.
The photoeffect is characteristic for photons with rather low energy and occurs mainly on electronах internal level of atoms. Photons with the energy changing in enough wide limits cause Kompton - effect at interaction of photons with electrons the external levels poorly connected with a kernel. The Kompton-effect occurs in substance in parallel (and it is independent) to a photoeffect.
In medicine use x-ray radiation with energy of photons from 60 up to 200 Кelectronvolt.
Х-
rays is weakened at interaction with substance. Buger’s
law
determines this weakening. Buger’s law for x-rays radiation looks
like
-
Stream of radiation, the past through substance
-
Stream of the radiation, falling on substance
-
linear factor of easing,
Linear factor of easing of x-ray radiation depends upon natures of substance.
Where
-
factor of true absorption,
-
factor of dispersion of primary radiation
Radiation
with the same length of a wave absorbs the more strongly, than it is
more density and more nuclear number Z. The bone absorbs Х-beams
more strongly, than soft tissues of the person. If a non-uniform body
to place on a way of a bunch of the x-ray radiation, the fluorescing
screen to place before it the shadow is formed on the screen because
of non-uniform absorption. This shadow allows to judge an internal
structure of a body. The bones, consisting in basic from
,
almost in 150 times absorb more strongly, than soft tissues
(consisting basically from water
).
Radioactivity radiation Radioactive disintegration Structure of a nucleus
The nucleus of atoms consists of elementary particles - protons and the neutrons, which are named nucleons. Protons and neutrons - independent particles in a free condition, but they can transformation earth other in a nucleus and then they are considered as various conditions of the same particles. Quantity Z of protons in a nucleus is equal to atomic number of an element. The mass number A is the integer number approximately equal to atomic mass of element (isotope).
The quantity of neutrons in nucleus is equal to a difference between mass number and atomic number of element (isotope):
N = A - Z
The radius
of a nucleus is determined by approximately formula: R=1.5
-13,
it has the order 10-13
sм
(in
105
times less then order of radius of atom).
Nuclear forces. Properties of nuclear forces. Models of nuclear forces
Nucleons in a nucleus are connected by special forces of a mutual attraction - nuclear forces. The nature of nuclear forces is not enough studied; however its basic properties are installed authentically.
1. Nuclear forces is short-range
2. Nuclear forces is strong
3. Nuclear forces operate act between nucleons irrespective of their electric charge. Nuclear forces act between two neutrons, and between a neutron and a proton or two protons.
4. Nuclear forces have properties of saturation, i.e. each nucleon interaction with only limited quantity of nucleons surrounding it, therefore if to increase quantity of nucleons in a nucleus, then nuclear forces do not increase, as it takes place for forces of electrostatic pushing away between protons. Stability of a nucleuses is weakened in process of increase of the general quantity of nucleons in nucleus (quantity of neutrons more then quantity of protons - N/Z>1.6). Nucleus such chemical elements have the spontaneous disintegration.
We have two kings of structure of atomic nucleus. Nucleons unbrokenly exchange special particles in a nucleus, which are named π-meson or quantum of a nuclear field, according to the theory accepted now. This is very difficult to determine independent to existence of these particles in nucleus, because the exchange to π-meson happens very quickly (during 10-23), therefore π-meson is named virtual.
Energy of connection of nucleons.
There is definition of energy of connection Ec. The energy of connection is a difference between general potential energy Е all free nucleons and potential energy Еn of nucleons, which there are inside nucleus Еc=Е-Еn. Energy of connection is an energy, which is allocated at formation of a nucleus from free nucleons, or accordingly energy, which is spend if action of external forces to destroy a nucleus. Energy of connection of a nucleus is proportional to quantity of nucleons, therefore we can use average value of energy the connections, falling one nucleon, which is named specific energy Es of connection
Еs = Еc/A (A - mass number).
