- •Contents:
- •Introduction
- •Structure, functions and methods of research of biological membranes The general structure of cell
- •Ultrastrucrure and function of function of biological membrane
- •Kinds of passive transport
- •Methods of research of structure and functions of biological membranes
- •Method of a dark field.
- •Phase - contrast method.
- •Electronic microscopy.
- •Method of diffraction of X-rays radiation.
- •Ultramicroscopy.
- •Luminescent methods of research of membranes.
- •Method of ultrachemistry.
- •Nuclear magnetic resonance research and electronic paramagnetic resonance research.
- •Research of forces of a superficial tension Properties of liquids
- •Superficial tension.
- •Physical properties of biological membranes.
- •Molecular mechanisms of electrochemical potentials of membranes and distribution of a nervous impulse along excitability fibre.
- •Principles of transformation of biological and not electric signals in electric. Designs of sensors and electrodes, their basic characteristics
- •Application of sensors
- •Analog registering devices
- •Rhythm of heart. Parameters of cardiac activity.
- •External displays of activity of heart.
- •Activity of heart
- •Electric activity of cells of a myocardium
- •Functions of conductive system of heart
- •The electrocardiogram
- •Change of a rhythm of cardiac activity.
- •The device and main principles of work of electrocardiograph
- •Imposing of electrodes
- •The device, a principle of work of electroencephalograph. Basic rhythms of eeg. Registration of eeg and principles of the analysis
- •Introduction
- •Essence of a method
- •Technique of record of electroencephalogram.
- •Principles of analyses of electroencephalogram
- •Definition of a photoeffect
- •Types of photoeffects.
- •Einstein equation
- •Application of a photo effect in medicine.
- •The device, principle of work spectrophotometer. Application spectrophometrical methods of research for definition of concentration of substances in biological liquids
- •Method of the calibre graph.
- •Method of comparison.
- •Polarization of light by biosystems. Polarimeter. Light natural and polarized. Polaroids.
- •Research of microstructures in polarizing light
- •Rotation of a plane of fluctuations of polarized light. Saccharimetry.
- •Design of the device
- •Principle of action
- •Special receptions of microscopy of biological objects Special methods of light microscopy (illumination and supervision). Method of a dark field.
- •Method of ultramicroscopy
- •Method of a light field and its version
- •Method of phase contrast
- •Polarizing microscopy
- •The method interference contrast
- •Method of research in a view of a luminescence
- •Device of a microscope. Measurement of value of microscoping object.
- •Model of sliding strings. Biomechanics of a muscle. The equation of Hill. Modeling of muscular reduction Biophysics of muscular reduction
- •Structure of a cross-section-striped muscle. Model of sliding strands.
- •Biomechanics of a muscle
- •The equation of Hill. Power of single reduction.
- •Modelling of muscular reduction
- •Electromechanical interface in muscles
- •Devices for measurement of function of external breath. The device and a principle of work. Registration and the analysis of the given functional researches
- •Change of saturation by gases of an organism at differences of external pressure.
- •Biomechanics of external breath
- •Devices for measurement of function of external breath
- •Viscosity of a liquid
- •Current of a liquid on a horizontal pipe. Puazal’s law.
- •Current of a liquid on a pipe of variable section and branched out
- •Definition of speed of blood-groove
- •Full resistance (impedance) of tissues of the organism Physical bases of rheography
- •Measurement of factor of viscosity.
- •Physical bases of hemodynamic. Laws of movement of blood in an arterial and venous channel
- •Measurement of pressure of blood
- •Systolic and minute volume of a blood-groove
- •Change of minute volume of a blood-groove at work.
- •Biophysical features of an aorta.
- •Biophysical features of arterioles of the big circle of blood circulation.
- •Tomographic methods
- •Classification of kinds of a tomography.
- •Interposition of a source of probing radiation, bject and the detector.
- •Echosounding
- •Computer tomograph.
- •Magnetic-resonant tomography.
- •Three-dimensional ultrasonic
- •ElastoScan-flexography
- •Modes of an acoustic transparency of three-dimensional ultrasonic.
- •Methods of physiotherapeutic influence
- •The therapeutic techniques based on application of a direct current. Electrophoresis and galvanizing in a medical practice. Mobility of ions.
- •Medicinal electrophoresis.
- •Galvanizing.
- •Electrosecurity
- •The basic requirements to an electrosecurity of electromedical devices and devices.
- •Modelling of biophysical processes.
- •The basic stages of modelling
- •The basic stages of modelling
- •4. Creation of model, its research.
- •Classification of models:
- •Mathematical models of growth of number of a population.
- •Pharmacokinetic model.
- •Sources of X-ray radiation.
- •Artificial sources of radiation.
- •Interaction of X-ray radiation with substance.
- •1. Coherent dispersion;
- •2. Photoeffect
- •3. Kompton - effect
- •Radioactivity radiation Radioactive disintegration Structure of a nucleus
- •A radioactive disintegration. Kinds of radioactive radiation
- •It is thrown out and a nucleus has more stability complex of nucleons. Positron β-disintegration is described by the equation:
- •The basic law of radioactive disintegration in the differential form. A constant of disintegration.
- •The basic law of radioactive disintegration in the differential form.
- •A half-life period.
- •Activity. A unit of measure.
- •Radioactive elements in the nature.
- •Ionizing radioactive radiation and its biological action.
- •The absorbed and exposition doze. Power of a doze. Units of measure.
- •Relative biological efficiency.
- •Mehanisms of action of laser radiation on biological tissues.
- •Mechanisms of action of laser radiation on biological tissues
- •Список использованной литературы :
- •Educational handout on medical biophysics kovaleva larissa valentinovna
Measurement of pressure of blood
Measurement of pressure in a blood vessel can be made by introduction in a vessel of the hollow needle connected by a rubber tube with a manometer. The similar way is used in experiment on animals.
I
n
a surgical practice direct measurement of pressure in cavities of
heart is made by a method of catheter,
entering
through one of large vessels thin polyethylene
probe
on which end there is a tiny electric manometer
In clinic the indirect bloodless way of measurement of a blood pressure is applied. Pressure is measured, which is necessary for putting outside to compress an artery before the termination in it of a current of blood. This pressure is rather close to pressure of blood in an artery. Measurement is usually made on a humeral artery above an elbow bend (fig.3)
Compression of an artery is carried out by means of a cuff M (the flat rubber chamber in fabric cover), which wrap up around of a shoulder and, working as supercharger Н, fill air to necessary pressure. The size of pressure is defined on manometer Р connected to a cuff. The method of measurement of arterial pressure on Korotkov is most widespread. This method is based on auscultation of the sounds which have arisen at passage of blood through an artery compressed by a cuff. For measurement of pressure it is necessary to do following actions:
To put on a cuff па a shoulder of the patient, to grope pulse of a humeral artery a little above an elbow bend and inside from a two-headed muscle.
To put to this place a stethoscope.
To close the crane of a supercharger and, rhythmically compressing and releasing a pear, to fill a cuff with air up to pressure upon 10-20 mm of a mercury column above at what pulse ceases to be probed on a beam artery.
Slowly rotating the final screw of a supercharger, pressure gradually is reduced in a cuff and sounds appearing in a stethoscope are listening.
The parity between change of pressure p in a cuff and «Korotkov's tones» it is shown schematically on fig.4.
PS - systolic (in norm of 100-120 mm of a mercury column), Pd - diastolic (70-80 mm of a mercury column) pressure.
W
hile
the artery is compressed completely, any sounds are not listened. At
decrease in a cuff of pressure start to be listened the tones
is called initial.
There is a pulse on a beam artery. These tones are caused by
vibration of walls of an artery directly behind a cuff under action
of pushes from portions of blood which break through the site of a
vessel compressed by a cuff only during the moments of a systole of
heart (the maximal pressure). Indications of a manometer, at the
first occurrence of tones, correspond maximal or systolic pressure.
At the further pressure decrease in a cuff tones are supplemented
with noise which becomes sometimes stronger than tones.
These noises are caused, apparently, by turbulent current of blood: through site of an artery partially squeezed by a cuff. Then noise abate and in a phonendoscope only tones named consecutive again are listened. These tones quickly weaken, and the sound phenomena stop. It occurs at full restoration of a gleam of an artery and an establishment of normal laminar current of blood. Indications of a manometer, during the moment of sharp reduction of loudness of tones, correspond minimal or diastolic to pressure.
The device for measurement of arterial pressure consists of three basic parts: cuff of M, supercharger Н and a manometer Р.
