Indications:

- generalized or definitely excessive fibrinolysis of various origins, which leads to dangerous bleeding that cannot be eliminated by conventional methods; - an overdose of fibrinolytic drugs or an excessive reaction to them; - for prophylactic purposes in case of injuries (including operative ones) of organs rich in activators plasminogen (lungs, uterus, pancreas, prostate glands); - placental abruption, intrauterine fetal death; - massive blood transfusions, extracorporeal circulation; septic conditions; radiation sickness, - pulmonary hemorrhage in tuberculosis, bronchiectasis, mitral stenosis; gastric bleeding with peptic ulcer, bleeding from the veins of the esophagus, intestinal bleeding.

MECHANIZATIONM: (BRIEFLY) blocks plasminogen activators, inhibits the action of plasmin, inhibits kinins. Shows a hemostatic effect in bleeding associated with increased fibrinolysis. exhibits antiallergic effect, increases the antitoxic function of the liver.

(COMPLETELY) bind already active plasmin. The resulting complex does not possess fibrinolytic activity, is sufficiently stable and undergoes insignificant dissociation. In addition, polypeptides inhibit the plasmin proactivator and the process of plasminogen activation. The spectrum of action of inhibitors extends to other proteolytic enzymes (see “Inhibitors of proteolytic enzymes”), in particular to kallikrein, under the influence of which kinins are formed - bradykinin and kallidin (they take part in the development of inflammatory and allergic reactions, as well as in the activation of the process fibrinolysis).

Indications: bleeding after operations on the lungs, prostate, pancreas and thyroid glands, premature placental abruption, with a dead fetus in the uterus, liver disease, pancreatitis, hypoplastic anemia.

Contraindications: thrombosis, embolism, pregnancy, kidney disease, for the prevention of bleeding during childbirth (possible thromboembolism after childbirth).

Side effects: dizziness, nausea, diarrhea, inflammation in the upper respiratory tract.

Amnocaproic acid - acts quickly, after 4 hours it is excreted by the kidneys.

Tranexamovaya to-that - the mechanism is the same, more active, it lasts longer.

Contrikal - directly inhibits fibrinolysin, proteolytic enzymes. Used for pancreatic necrosis, heart attack, coronary artery disease.

115. Sulfanilamide preparations. Defecation. Mechanism of action. The nature of the action. Spectrum of action. Indications for use. Side effects. Contraindications Comparative evaluation of drugs. Combined preparations of sulfonamides with trimethoprim.

Sulfanilamide preparations Is a group of antimicrobial drugs, the structure of which is based on sulfanilic acid.

Classification:

1) Preparations well absorbed from the gastrointestinal tract (resorptive sulfonamides), creating a high concentration in the blood and organs:

1. Short-acting (<10 h)

"SULPHANYLAMIDE"

SULFADIMIDINE

2. Medium duration of action (10-24 hours)

SULFADIAZINE

SULFAMETOXAZOLE

3. Long-acting (24-48 hours)

SULFAMONOMETOXIN

SULFADIMETOXIN

4. Ultra-long acting (> 48 h)

SULFALENE

SULFADOXIN

2) Drugs that are poorly absorbed in the gastrointestinal tract, creating a high concentration in the large intestine:

phthalazole

sulgin