Indications for use:

1. Amenorrhea.

2. Anovulatory uterine bleeding.

3. Infertility associated with dysfunction of the corpus luteum.

4. Habitual or threatening miscarriage.

5. Algodismenorrhea against the background of hypogenitalism.

6. Endometriosis.

7. For the purpose of contraception.

Side effects:

1. With intramuscular injection:

- thromboembolism, thrombophlebitis;

- galactorrhea;

- cholecystitis, cholestatic hepatitis;

- edema;

- alopecia;

- allergic reactions;

2. When taken orally - sleep disturbances, dizziness, dyspeptic disorders.

Contraindications:

1. Liver dysfunction.

2. Hepatitis.

3. Tendency to thrombosis.

Antigestogenic agents

Mifepristone competitive antagonist of natural progestins.

Apply for early termination of pregnancy (up to 42 days), in rare cases for the treatment of menstrual irregularities.

Side effects: uterine bleeding, discomfort and pain in the lower abdomen, weakness, headache, nausea, vomiting.

Contraindications: pregnancy over 42 days, adrenal insufficiency, impaired hemostasis, anemia.

4. Antimalarial drugs. Classification. Mechanism of action. Indications for use. Side effects. Contraindications Comparative evaluation of drugs.

Classification of antimalarial drugs

by chemical affiliation of drugs

P / p #	Group chemical compounds	A drug
one.	4-methanolquinoline derivatives	quinine, mefloquine
2.	7-chloroquinolines	hingamin (delagil)
3.	4-Aminoquinolines	chloroquine, amodiaquine
four.	Acridines	akrikhin, aminoacriquine,
five.	8-Aminoquinolines	primaquine, quinocide
6.	Biguanides	bigumal
7.	Diaminopyrimidines	chloridine, trimethoprim
eight.	Sulfonamides	sulfapyridazine, sulfamethoxin, sulfalene, sulfadimethoxine
nine.	Tetracyclines	tetracycline, doxycycline
10.	Combined drugs	fancidar

Classification of antimalarial drugs

on the spectrum of antimalarial action

Spectrum of action	Drugs
1. Blood schizocytic drugs (destroy asexual forms of plasmodia in the stage of schizogony in erythrocytes)	Quinine, Akrikhin, hingamin, chloridine, fancidar
2. Primary tissue schizontocytic agents (affect the pre-erythrocytic tissue forms of plasmodia)	Bigumal, chloridin, fancidar
3. Secondary tissue schizontocytic agents (destroy para-erythrocytic tissue forms of plasmodia)	Chloridine, primaquine, hinocid, fancidar
4. Gametocidal agents (inhibit the development of gametes)	Quinocid, primaquine, chloridine, fancidar
5. Sporontocidal agents (block the sexual development cycle of gametes in the body of a mosquito)	Bigumal, chloridin, fancidar

By the mechanism of action of group 2: Group 1 includes antimalarial drugs with a strong schizontocidal effect. The mechanism of action of these drugs is not specific. They disrupt the properties of both microbial DNA and human cells. This group includes acriquine, chloroquine, primaquine and quinine.

The drugs of the second group are characterized by schizontocidal action, which occurs rather slowly. Resistance to them develops easily both in experiment and in practice. Their mechanism of action is specific. They competitively displace para-aminobenzoic acid (PABA) from the enzyme systems of the microbial cell, but they cannot perform the function of this metabolite. The drugs either interfere with the conversion of PABA to folic acid, or block dihydrofolic reductase. They have no effect on the cells of the macroorganism. This group includes bigumal, chloridine and their derivatives, as well as sulfonamides.